http://repository.usmf.md:80/handle/20.500.12710/821 2026-05-02T10:00:08Z 2026-05-02T10:00:08Z Strukov, A. Serov, V. http://repository.usmf.md:80/handle/20.500.12710/27815 2024-09-16T10:53:48Z 1999-01-01T00:00:00Z

Title: Anatomia patologică Authors: Strukov, A.; Serov, V.

1999-01-01T00:00:00Z Zota, Ieremia Vataman, Vladimir http://repository.usmf.md:80/handle/20.500.12710/2004 2024-09-16T10:41:53Z 2010-01-01T00:00:00Z

Title: Morfopatologie generală Authors: Zota, Ieremia; Vataman, Vladimir

2010-01-01T00:00:00Z Zota, Ieremia Burkes, Ernest Jefferson Vataman, Vladimir http://repository.usmf.md:80/handle/20.500.12710/2003 2024-09-16T10:28:56Z 2004-01-01T00:00:00Z

Title: General morphopathology: a compendium and atlas Authors: Zota, Ieremia; Burkes, Ernest Jefferson; Vataman, Vladimir

2004-01-01T00:00:00Z Melnic, Eugen http://repository.usmf.md:80/handle/20.500.12710/2002 2019-06-22T14:06:27Z 2015-01-01T00:00:00Z

Title: The influence of the tumoral cell proliferation rate in pituitary adenoma on expressing other factors with a prognostic role and therapeutic potential Authors: Melnic, Eugen Abstract: Background: This article describes the growth rate of pituitary adenomas, their invasion and potential recurrence. Some of them grow rapidly while others remain in a dormant condition for a long time. The recurrence rate is also very hard to forecast. The pituitary adenomas that initially reduced their proliferation rate now acquire a rapid one, producing aggressive recurrences. Materials and methods: Eighty two cases of pituitary adenomas were studied. The classification of human pituitary adenomas has been profoundly assisted by immunohistochemistry. Ki-67 antibody was used to assess the proliferative index of pituitary adenomas. Results: Acidophil type adenomas or acidophil cells areas within mixed pituitary adenomas had the highest proliferation rate. Chromophobe pituitary adenomas were Ki67 negative in 90%, as well as the ones that presented the basophilic cells. The pituitary adenomas with a trabecular growth pattern had the lowest rate of proliferation, in about 50% of the cases being zero. The heterogeneity expression of growth factors and corresponding receptors is dependent on hormonal profile of pituitary adenomas. Conclusion: The pituitary adenomas proliferation rate depends on the type of secreted hormone as well as on the hormonal associations met in some cases of pituitary adenomas. Description: Department of Morphopathology, Nicolae Testemitsanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova

2015-01-01T00:00:00Z