http://repository.usmf.md:80/handle/20.500.12710/12305 2026-04-12T17:53:49Z http://repository.usmf.md:80/handle/20.500.12710/16553 Title: The Moldovan Medical Journal. September 2019, Vol. 62, No 3 Abstract: The Moldovan Medical Journal is an international scientific double-blind peer reviewed periodical edition, 4 per year, of the Scientific Medical Association of the Republic of Moldova designed for specialists in the areas of medicine, dentistry, pharmacy, social medicine and public health. From its debut the journal has striven to support the interests of Moldovan medicine concerning the new concepts of its development. The Editorial Board warmly welcomes both the readers of and the authors for the journal, all those who are enthusiastic in searching new and more effective ways of solving numerous medicine problems. We hope that those who want to make their contribution to the science of medicine will find our journal helpful and encouraging. Description: Fondatori: Ministerul Sănătăţii al Republicii Moldova, Universitatea de Stat de Medicină şi Farmacie “Nicolae Testemiţanu” 2019-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/14170 Title: The monograph “Biological unity of the nature and man: an esthetics-anthropological research with emphasis on phylogenesis and ontogenesis features of oro-maxillo-facial system”. The author: Alexander Postolachi Authors: Lomiashvili, Larisa Description: Dental Faculty, Head of Therapeutic Stomatology Department State Medical University of Omsk, Russia 2019-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/13612 Title: The orthodontic miniscrew implants in tooth migration Authors: Paz, Elinor; Babuci, Angela; Stepco, Elena Abstract: Background: The bone loss, tooth loss and gingival inflammation are the most common harmful factors that might cause pathologic tooth migration. Taking into consideration that miniscrews implants are used in orthodontic treatment of both pathologic and physiologic tooth migration, we were interested to mark out the advantages and disadvantages of miniscrew usage. Conclusions: Development of implants industry and particularly miniscrew anchorage has been rapidly increased in the recent years, but nevertheless there still are some risk factors of miniscrews use and success of treatment depends a lot on techniques of miniscrew insertion and stability elements. The anchorage control during tooth movement is one of the main factors for ensuring successful orthodontic treatment and the most important keys for achievement of success in clinical orthodontics. The advantages of miniscrews, in comparison with other methods of orthodontic treatment might be resumed to: lower costs, easy placement, no need for patient cooperation, high quality and efficiency of treatment. Among the most undesirable side effects of miniscrews use can be marked out the screw fracture, screw-root proximity, damages of soft and hard tissues, displacement under orthodontic loading, etc. Description: Department of Human Anatomy, Department of Pediatric Oral and Maxillofacial Surgery Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova 2019-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/7009 Title: The key players of tumor microenvironment and their role in breast cancer Authors: Carpenco, Ecaterina Abstract: Background: Cancer studies were focused mainly on tumor cells. But not that much time passed since researchers began to focus not only on neoplastic cells, but also on significant alterations in the surrounding stroma or tumor microenvironment. These alterations are now recognized as a critical element for breast cancer development and progression, as well as potential therapeutic targets. Different elements of the breast cancer microenvironment (such as immune cells, soluble factors and modified extracellular matrix) act together to stop effective antitumor immunity and stimulate breast cancer progression and metastasis. Stromal cells in the breast cancer microenvironment are characterized by molecular alterations and aberrant signaling pathways, some of which are prognostic factors for clinical outcome. Conclusions: Tissue microenvironment has profound effects on the progression of cancer cells by its paracrine signaling. Molecular characterization of various cell types from the normal breast tissue, ductal carcinoma in situ and invasive breast tumor revealed significant changes in gene profile in all cell types during breast tumor progression. Microenvironment changes influence tumor progression as well as the efficacy of various cancer therapies. There is compelling evidence that the elements of tumor microenvironment respond to different stimuli and release distinct mediators, some antitumorigenic, while others protumorigenic activity. Each of the known players of breast stroma involved in tumorigenesis and cancer progression can be influenced and directed towards an “anticancer” state. Description: Department of Histology, Cytology and Embryology, Laboratory of Morphology, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova 2019-01-01T00:00:00Z