http://repository.usmf.md:80/handle/20.500.12710/162 2026-04-09T02:33:16Z http://repository.usmf.md:80/handle/20.500.12710/27427 Title: Traumatisme vasculare. Diagnostic și tratament contemporan: Ghid metodologic pentru studenți, medici rezidenți chirurgi și medici specialiști în chirurgie Authors: Țurcan, Aurel; Castraveț, Alexandru; Popa, Radu F.; Ștefaneț, Anatolie; Cheptănaru, Eduard; Rusu, Victoria; Cojocaru, Victor; Ciubotaru, Anatol 2023-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/23614 Title: Natriuretic peptides in elderly patients with chronic obstructive pulmonary disease Authors: Bodrug, Nicolae; Luca, Ecaterina Abstract: Background Natriuretic peptides (NPs) are considered a useful tool for diagnosing the cardiac or pulmonary origin of acute dyspnea in the emergency department. The aim of this study was to evaluate NP in elderly patients with chronic obstructive pulmonary disease (COPD). Materials and methods In the PubMed and Hinari databases, we identified 465 comprehensive articles in English, published in the years 1990–2021, which provided information on natriuretic peptides in elderly patients with COPD. The final bibliography contains 49 relevant sources. Results NP, specially BNP/NT-proBNP values are frequently elevated in patients with COPD, reflecting three complex aspects of the interrelated cardio-pulmonary continuum: (1) left ventricular systolic and diastolic dysfunction, (2) pulmonary vascular and right heart remodeling, (3) global cardiovascular risk and comorbidities. The additional increase in BNP/NT-proBNP values during acute exacerbation of COPD is probably a marker for both, acute estate of COPD and varying degrees of underlying cardiopulmonary disease. The results of the studies suggest the role of natriuretic peptides as relevant prognostic biomarkers not only for patients with cardiovascular disease, but also for patients with chronic obstructive pulmonary disease, which has an important clinical implication. The determination of these biomarkers in patients with chronic obstructive pulmonary disease allows stratification for prognosis: it is able to select a subgroup of patients at higher risk, which requires increased attention and optimization of treatment. Conclusion NPs, especially BNP/NT-proBNP are relevant prognostic biomarkers not only for patients with cardiovascular disease, but also for patients with COPD, acute exacerbations and haemodynamic disorders like PH and cor pulmonale. Estimating BNP/NT-proBNP in COPD patients has an important clinical implication: it allows the selection of a subgroup of patients at higher risk, which requires increased attention and treatment optimization. 2022-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/23613 Title: The frequency of pulmonary hypertension in chronic obstructive pulmonary disease of geriatric patients: a narrative literature review Authors: Luca, Ecaterina; Bodrug, Nicolae Abstract: Background Pulmonary hypertension (PH) is a serious complication with complex pathogenesis in the natural history of chronic obstructive pulmonary disease COPD, with a progressively increasing frequency with a meanwhile decreasing in functional capacity. Purpose Assessment of the incidence, pathogenesis, peculiarities, and complications of PH in COPD in geriatric population worldwide. Methods We performed an analysis of randomized, retrospective, and prospective clinical, case-control and observational studies, published at the international level, according to the subject studied and target population. Four hundred ninety-seven full articles were identified after the search through engine Google Search and databases PubMed, Hinari, SpringerLink, and Scopus (Elsevier) according to the keywords and subsequent filters. Results Depending on various factors, like the population examined, the definition used for mPAP (mPAP> 20 mm Hg or ≥25 mm Hg), the severity of the lung disease, and the method of measuring PAP, a varied incidence of COPD patients with PH complication was discovered, namely 10–91%. PH prevalence increases with the COPD severity. The presence of PH is associated with acute exacerbations of COPD, reduced survival, and increasing expenses for healthcare programs. Mild to moderate levels of PH (mPAP 25–34 mm Hg) are relatively common in COPD and usually are associated with severe airflow obstruction or parenchymal destruction. Only a minority of patients (1–5%) have severe PH (mPAP ≥35 mm Hg). Conclusions Diagnosis of PH in COPD is difficult, especially in a mild form, and requires a clinical approach associated with a comprehensive set of investigations for confirming the etiology, evaluation of the functional and hemodynamical impairment severity, and important factors in the appropriate treatment election. 2022-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/19849 Title: Innovative approaches to the treatment of gastroesophageal reflux disease complicated with metaplasia of columnar esophagus Authors: Fosa, Doina 2019-01-01T00:00:00Z