http://repository.usmf.md:80/handle/20.500.12710/18200 2026-04-10T14:07:57Z http://repository.usmf.md:80/handle/20.500.12710/18247 Title: Manifestările neurologice în COVID-19 în populația pediatrică (Reviu) Authors: Calcîi, Cornelia; Hadjiu, Svetlana; Sprîncean, Mariana; Revenco, Ninel Abstract: Since the first reports of SARS-CoV-2 infection from China, multiple studies have been published regarding the epidemiologic aspects of COVID-19 including clinical manifestations and outcomes. The majority of these studies have focused on respiratory complications. However, recent findings have highlighted the systemic effects of the virus, including its potential impact on the nervous system. Similar to SARS-CoV-1, cellular entry of SARS-CoV-2 depends on the expression of ACE2, a receptor that is abundantly expressed in the nervous system. Neurologic manifestations in adults include cerebrovascular insults, encephalitis or encephalopathy, and neuromuscular disorders. However, the presence of these neurologic findings in the pediatric population is unclear. In this review, the potential neurotropism of SARS-CoV-2, known neurologic manifestations of COVID-19 in children, and management of preexisting pediatric neurologic conditions during the COVID-19 pandemic are discussed.; Со времени первых сообщений об инфекции SARS-CoV-2 из Китая было опубликовано множество исследований, касающихся эпидемиологических аспектов COVID-19, включая клинические проявления и исходы. Большинство этих исследований были сосредоточены на респираторных осложнениях. Однако недавние открытия высветили системные эффекты вируса, включая его потенциальное воздействие на нервную систему. Подобно SARS-CoV-1, клеточный вход SARS-CoV-2 зависит от экспрессии ACE2, рецептора, который в изобилии экспрессируется в нервной системе. Неврологические проявления у взрослых включают нарушения мозгового кровообращения, энцефалит или энцефалопатию, а также нервно-мышечные расстройства. Однако наличие этих неврологических находок в педиатрической популяции остается неясным. В этом обзоре обсуждается потенциальный нейротропизмSARS-CoV-2, известные неврологические проявления COVID-19 у детей и лечение ранее существовавших детских неврологических состояний во время пандемии COVID-19. Description: Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu”, Departamentul Pediatrie, IMSP Institutul Mamei și Copilului 2021-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/18246 Title: Buletin de perinatologie. 2021, Nr. 2(91) Abstract: Revistă științifico–practică. Fondată în anul 1998. Description: Fondatori: Institutul Mamei și Copilului, Societatea de Pediatrie din Republica Moldova 2021-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/18245 Title: Factori determinanți ai obezității la copil Authors: Negrea, Mihai Octavian; Costache, Victor Sebastian Abstract: Introduction. The usual approach when defining the fundamental etiology of obesity is to consider the energy imbalance between calories consumed and calories expended as the main determinant factor in the pathogenesis of weight excess [1]. In recent times, considerable scientific efforts have been made, however, to provide nuance regarding the inner workings of the exact mechanisms that lead to the development of obesity [2]. One direction for research has revolved around the factors regarding childhood obesity – an illness which is escalating globally [3, 4]. There is a well-documented relation between developing a weight excess in childhood and adult obesity [5], as a majority of overweight adults have in fact retained this status since childhood [6]. Preventive action against obesity is dependent upon the understanding of its determinant factors. These factors represent targets upon which to act in order to attempt to minimize the impact of this global disease. Aim of the study. To provide an overview of the current literature regarding the main determinant factors of childhood obesity and identify potential targets for preventive measures in this respect. Material and methods. We performed literature searches using the Medline/ PubMed databases and referred to international guidelines where applicable. Results and conclusions. The intricate interactions between environment and genotype can reveal a series of crucial points where decisive preventive actions could have a significant impact on the reduction of the burden of obesity. Description: Institutul Inimii de Urgență pentru Boli Cardiovasculare „Niculae Stăncioiu” Cluj-Napoca, județul Cluj, România, Universitatea „Lucian Blaga” din Sibiu, județul Sibiu, România 2021-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/18244 Title: Particularități ale infecției de tract urinar la copiii cu factori favorizanți locali Authors: Mătăcuţă-Bogdan, Ioana Abstract: Introduction. Urinary tract infection is a major cause of morbidity and mortality inpediatric population. The association of risk factors sheds new light on its etiology, epidemiology, diagnosis and therapy, but also on the monitoring. The material and scientific methods used are those of reviewing data from the literature on current data, controversies, discrepancies and peculiarities related to urinary tract infection in children with local risk factors. The epidemiological aspects are highlighted as well as the characteristics of the urinary tract infection associated with different risk factors. The results focus on those elements of novelty in terms of identification, monitoring, therapy and prophylaxis of these infections, with implications for current practice. Conclusions. Urinary tract infection in children with local risk factors is characterized by particularities regarding etiology, evolution, treatment and prognosis. The study outlines the indications for antibiotic prophylaxis, respectively the cases in which there is evidence that the benefits are maximum.; Introducere. Infecția de tract urinar este o cauză importantă de morbiditate și mortalitate în populația pediatrică. Asocierea factorilor de risc aruncă o nouă lumină în ceea ce privește etiologia, epidemiologia, diagnosticul și terapia acesteia, dar și asupra modalităților de monitorizare. Materialul şi metodele ştiinţifice folosite, sunt acelea de trecere în revistă a datelor din literatură privind datele actuale, controversele, discordanţele şi particularităţile referitoare la infecția de tract urinar la copilul care prezintă factori de risc locali. Sunt evidențiate aspectele epidemiologice, dar și caracteristicile infecției de tract urinar în funcție de diferiții factori de risc identificați. Rezultatele sunt centrate pe acele elemente de noutate în ceea ce privește identificarea, monitorizarea, terapia și profilaxia acestor infecții, cu implicații în practica curentă. Concluzii. Infecția de tract urinar la copiii cu factori de risc locali se însoțește de particularități etiologice, de evoluție, tratament și prognostic. Din studiul acestor factori se contureaza indicațiile pentru profilaxia antibiotic, respective cazurile în care există dovezi că beneficiile sunt maxime. Description: Universitatea ”Lucian Blaga”, Facultatea de Medicină, Sibiu, România, Spitalul Clinic de Pediatrie din Sibiu, Centrul de Cercetări şi Telemedicină în Bolile Neurologice la copil 2021-01-01T00:00:00Z