http://repository.usmf.md:80/handle/20.500.12710/28261 2026-04-11T23:05:30Z http://repository.usmf.md:80/handle/20.500.12710/30095 Title: Acute autoimmune hemolytic anemia in a patient with systemic lupus erythematosus Authors: Chirca, Vera; Popa, Serghei; Agachi, Svetlana; Dutca, Lucia; Corotaș, Valeriu Abstract: Introduction. Autoimmune hemolytic anemia occurs due to the accelerated destruction of erythrocytes as a result of the dysfunction of immune system cells, which produce antibodies against the normal antigens of the membrane of hematopoietic cells. One of its causes is systemic lupus erythematosus. Materials and methods. We present a case of a 20-year-old patient who was hospitalized with acute autoimmune hemolytic anemia, having been diagnosed with SLE at the age of 18 years. At the onset of the disease, hemolytic anemia was a differential diagnostic challenge. Results. The differential diagnosis between primary and secondary autoimmune hemolytic anemia (AIHA) was an important step. The presence of antinuclear antibodies (ANA Hep2, Anti-dsDNA, Anti-cardiolipin, Anti-phospholipids, anti-Ro, Anti-Sm B) were important arguments in making the diagnosis. The relapse of AIHA was caused by inadequate treatment, due to a lack of compliance. Pulse therapy combined with methylprednisolone and cyclophosphamide successfully resolved the AIHA. Conclusions. Hematological abnormalities are commonly seen in SLE patients, but hemolytic autoimmune anemia is a rare condition. A timely diagnosis of the cause of hemolytic anemia and proper treatment of lupus by correcting autoimmune disorders are crucial in disease management. Pulse therapy combined with corticosteroids and immunosuppressants is effective in acute relapses of hemolytic anemia. 2024-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/30094 Title: Management of diabetic retinopathy in pregnancy Authors: Șcerbatiuc, Cristina Abstract: Introduction. The onset and development of diabetic retinopathy are more common during pregnancy. Pregnancy has no long-term effect on diabetic retinopathy; however, in 50-70% of cases, changes in retinopathy continues. The probability of worsening is highest in the second trimester and up to one year postpartum. Additional factors that have been associated with disease progression include duration of diabetes, the degree of retinopathy at the time of conception, management of hyperglycemia, anemia, and development of associated hypertension. In cases of severe non-proliferative retinopathy, it is recommended to promptly initiate laser photocoagulation rather than wait for early proliferative changes. Maintaining good diabetic control before and during pregnancy can help prevent disease progression and serious vision loss. Material and methods. Diabetic retinopathy management in pregnancy was the subject of a comprehensive review of the scientific and medical literature. A structured search was performed in the PubMed, Scopus and HINARI databases, considering relevant articles published in the last 10 years. The search terms used (in English) were: „Diabetic retinopathy”; „pregnancy”; „laser photocoagulation”; „intravitreal steroids”; „anti-vascular endothelial growth factor”. Results. It is suggested that women with diabetes receive pre-conception and post-pregnancy counselling from a multidisciplinary team including an ophthalmologist, endocrinologist, and perinatologist, as diabetic retinopathy may worsen during pregnancy. The risk of progression of the disease and the importance of appropriate metabolic control before and during pregnancy should be clearly explained to the patient. Careful monitoring is required in patients with advanced gestation, significant retinopathy, concomitant hypertension, and nephropathy. Conclusion. The risk of retinopathy development may increase during pregnancy. Serious effects can arise for both the mother and the fetus, even though retinopathy is not common during pregnancy. It is possible to avoid significant retinopathy by carefully planning a young diabetic woman’s pregnancy and proceeding promptly to laser photocoagulate in cases of severe non-proliferative retinopathy. A tendency for regress is frequently seen in diabetic retinopathy during the post-natal period. Subsequent pregnancies do not significantly increase the risk of progression if the retinopathy is stable before pregnancy. 2024-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/30087 Title: Temporary splinting in periodontally mobile teeth: review before application Authors: Ceban, Mariana; Ceban, Victor; Pântea, Vitalie Abstract: Introduction. Temporary splinting of mobile, periodontally compromised teeth is an important stage in the complex treatment of periodontitis, used to improve mastication, aesthetics, and the prognosis for teeth with pathological mobility. It helps prevent this phenomenon and consolidate the success of conservative and surgical treatment, which also has a positive effect on the patient’s psycho-emotional state. Materials and methods. 12 patients (6 female and 6 male), aged 26–60 years, with pathological teeth mobility due to chronic generalized periodontitis, were included in the study. Temporary splinting was performed using fiberglass threads braided with polyester microfibers, polyethylene fibers, and aramid fibers, and in all clinical cases, it was secured with photocomposite material designed for teeth splinting. Results. Temporary splinting is a very important step in periodontitis treatment, and dynamic monitoring is necessary throughout the entire period of splinting. The interval between visits is determined based on the type of splinting, the risk of complications, the severity of periodontitis, systemic and local factors, the level of individual oral hygiene, and the patient’s motivation. The interval can be 6 months, 4 months, or, in aggressive forms of periodontitis, 2 months. Conclusions. Temporary splinting contributes to the effectiveness of pathogenetic and symptomatic therapy. 2024-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/30084 Title: Comparative analysis of imaging data in sensory and motor disorders in lumbar neurocompressive syndrome Authors: Seu, Victoria; Malîga, Oxana Abstract: Introduction. Lumbar neurocompressive syndrome is a condition characterized by radicular pain, motor, sensory and reflex changes, as well as paresthesia or numbness in the lower limb. These symptoms can be triggered by positions and/ or movements of the spine. In lumbar radiculopathy, both mechanical and inflammatory factors play significant roles. Material and methods. The study included 102 patients with signs of lumbar neurocompressive syndrome. Of these, 51 (group I) patients were examined using MRI and the other 51 patients (group II) were examined using conventional radiographic investigation of the lumbosacral region of the spine. Results. By analyzing the magnetic resonance imaging data of the lumbar spine, a threshold of statistical significance was determined (of 10%, p < 0.10) for patients with sensory disturbances in the lower limb in cases of stenosis of the lumbar spinal canal, and in patients with motor disorders in the lower limb, in the case of disc protrusions. The analysis of the magnetic resonance imaging data determined a significance threshold (of 5%, p < 0.05) in patients with sensory disorders (in the case of disc sequestrations and in the case of disc extrusions) as well as for motor disorders (in the case of disc extrusions, disc sequestrations and static disorders of the spine). The analysis of standard radiographs of the lumbar spine allowed the determination of the threshold of statistical significance (of 5%, p < 0.05) in patients with sensory disorders in the lower limb in cases of coxofemoral osteoarthritis and Schmorl’s hernias. For patients with motor disorders at the level of the lower limb, conventional radiography was informative in the presence of calcification of the intervertebral discs and in coxofemoral osteoarthritis. Conclusion. MRI can be considered the first-choice imaging technique for diagnosis of the lumbar spine pathologies characterized by sensory and motor changes in the lower limbs. 2024-01-01T00:00:00Z