http://repository.usmf.md:80/handle/20.500.12710/610 2026-04-17T18:14:50Z http://repository.usmf.md:80/handle/20.500.12710/30897 Title: Clinical and evolutionary aspects of neuroinfections: a study from 2019 to 2024 Authors: Avricenco, Mariana; Otgon, Grigoria; Bistritchi, Ina; Cojocaru, Stela; Chiriacov, Galina; Baba, Lilia; Holban, Tiberiu Abstract: Background and objectives. Neuroinfections are significant due to their epidemiology, unpredictable nature, and diverse clinical manifestations. This study aimed to determine the characteristic of neuroinfections in patients admitted to an infectious diseases hospital. Materials and methods. The study was conducted on 106 patients with acute neuroinfections at the “T. Ciorba” Hospital for Infectious Diseases in the Republic of Moldova from 2019 to 2024. Results. Neuroinfections were suspected upon admission in 51 (48.1%) cases. The ratio of patients with aseptic CSF to those with septic CSF was 66 (62.3%) to 40 (37.7%) cases. Significant differences between aseptic vs septic CSF neuroinfections were observed for patient age 34.9±15.8 years and 19±18 years (p < 0.0001); headache 98.4% vs 67.5% (p < 0.0001); neck stiffness 72.7% vs 42.5% (p = 0.0021); vomiting 57.5% vs 77.5% (p = 0.0372); photophobia 37.8% vs 17.5% (p = 0.0280). The aetiology was identified or suspected in 28 (42.4%) patients with aseptic CSF compared to 36 (90%) with septic CSF. The disease progressed more severely in septic CSF cases – 92% (37 patients) vs 40.9% (27 patients) with aseptic CSF (p < 0.0001), and in children – 80.6% (25 cases) vs adults – 52% (39 cases) (p = 0.0064). Complications developed in 71 (66.9%) patients, primarily in septic meningitis. These included cerebral edema, toxic shock, pneumonia, reactive arthritis, and decreased cognitive abilities. A total of 10 patients (9.4%) died. Conclusions. Neuroinfections are a medical emergency in the Republic of Moldova, associated with frequent and potentially fatal sequelae. Timely management involves point-of-care diagnostics, including PCR tests, and early pathogen-directed therapy. Prioritization should focus on enhancing vaccination coverage and strengthening surveillance networks. 2025-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/5416 Title: Preliminary results for treatment with sofosbuvir and daclatasvir of patients with chronic hepatitis C Authors: Russu, Irina; Holban, Tiberiu; Pantilimonov, Tatiana; Chiriacov, Galina; Macvovei, Arcadie; Scorohodico, Elena; Dmitriev, Oleg Description: The 12th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Bals” and the 12th National Infectious Diseases Conference, 23–25 November 2016, Bucharest, Romania, Department of Infectious Diseases, Parasitology and Tropical Medicine, Nicolae Testemițanu State Medical and Pharmacy University, Chișinău, Republic of Moldova, Toma Ciorbă Clinical Hospital for Infectious Diseases, Chișinău, Republic of Moldova 2016-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/5415 Title: Внебольничные инфекции, обусловленные метициллинрезистентным стафилококком Authors: Ясыбаш, О.; Балан, Г.; Бунеску, И.; Бурдунюк, О. Description: Национальный центр общественного здоровья, г.Кишинев, Республика Молдова, Государственный университет медицины и фармации имени Николая Тестемицану, г.Кишинев, Республика Молдова 2017-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/5417 Title: Impact of late presentation in the treatment effectiveness for HIV-infected patients in the Republic of Moldova Authors: Micșanschi, Pavel; Holban, Tiberiu; Spinu, Constantin; Bîstrițchi, Ina; Nagîț, Angela; Cucerova, Irina; Ghitu, Elena Description: 13th Edition of the Scientific Days of the National Institute for Infectious Diseases “Prof. Dr. Matei Balș”, 08-10 November 2017, Bucharest, Romania, “Toma Ciorbă” Clinical Hospital for Infectious Diseases, Chișinău, Republic of Moldova, Hospital of Dermatovenerology and Communicable Diseases, Chișinău, Republic of Moldova, National Public Health Center, Republic of Moldova 2017-01-01T00:00:00Z