http://repository.usmf.md:80/handle/20.500.12710/639 2026-07-22T13:58:05Z http://repository.usmf.md:80/handle/20.500.12710/33462 Title: Core outcome set for the management of acute exacerbations of chronic obstructive pulmonary disease: the COS-AECOPD ERS Task Force study protocol Authors: Mathioudakis, Alexander G.; Abroug, Fekri; Agusti, Alvar; Bakke, Per; Bartziokas, Konstantinos; Beghe, Bianca; Bikov, Andras; Bradbury, Thomas; Brusselle, Guy; Cadus, Cordula; Coleman, Courtney; Contoli, Marco; Corlăteanu, Alexandru; Corlăteanu, Olga; Criner, Gerard; Csoma, Balazs; Emelyanov, Alexander; Faner, Rosa; Romero, Gustavo Fernandez; Hammouda, Zeineb; Horváth, Peter; Huerta, Arturo Garcia; Jacobs, Michael; Jenkins, Christine; Joos, Guy; Kharevich, Olga; Kostikas, Konstantinos; Lapteva, Elena; Lazar, Zsofia; Leuppi, Joerg D.; Liddle, Carol; López-Giraldo, Alejandra; McDonald, Vanessa M.; Nielsen, Rune; Papi, Alberto; Saraiva, Isabel; Sergeeva, Galina; Sioutkou, Agni; Sivapalan, Pradeesh; Stovold, Elizabeth; Wang, Hao; Wen, Fuqiang; Yorke, Janelle; Williamson, Paula R.; Vestbo, Jørgen; Jensen, Jens-Ulrik Abstract: Randomised controlled trials (RCTs) on the management of COPD exacerbations evaluate heterogeneous outcomes, often omitting those that are clinically important and patient relevant. This limits their usability and comparability. A core outcome set (COS) is a consensus-based minimum set of clinically important outcomes that should be evaluated in all RCTs in specific areas of health care. We present the study protocol of the COS-AECOPD ERS Task Force, aiming to develop a COS for COPD exacerbation management, that could remedy these limitations. For the development of this COS we follow standard methodology recommended by the COMET initiative. A comprehensive list of outcomes is assembled through a methodological systematic review of the outcomes reported in relevant RCTs. Qualitative research with patients with COPD will also be conducted, aiming to identify additional outcomes that may be important to patients, but are not currently addressed in clinical research studies. Prioritisation of the core outcomes will be facilitated through an extensive, multi-stakeholder Delphi survey with a global reach. Selection will be finalised in an international, multi-stakeholder meeting. For every core outcome, we will recommend a specific measurement instrument and standardised time points for evaluation. Selection of instruments will be based on evidence-informed consensus. Our work will improve the quality, usability and comparability of future RCTs on the management of COPD exacerbations and, ultimately, the care of patients with COPD. Multi-stakeholder engagement and societal support by the European Respiratory Society will raise awareness and promote implementation of the COS. 2020-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/33392 Title: Embolia pulmonară acută asociată cu tromboza acută a sistemului venos profund Authors: Ranga, Doina; Caproş, Natalia; Caproș, Hristiana Abstract: Scopul studiului a fost prezentarea unui caz clinic de EP la o pacientă tânără de 26 de ani cu o scurtă trecere în revistă a literaturii de specialitate. Particularitatea cazului cu embolie pulmonară prezentat a fost asocierea cu tromboza acută a sistemului venos profund și venei externe pe fon de anamnestic de utilizare a contraceptivelor orale combinate.; The purpose of the study was to present a clinical case of pulmonary embolism in a young patient of 26 years, with a brief review of the literature. The particularity of the presented case with the pulmonary embolism was the association with the acute thrombosis of the deep venous system venous system on background of combined oral contraceptives use.; Целью исследования было представить клинический случай легочной эмболии у молодой пациентки 26 лет с кратким обзором литературы. Особенностью случая с представленной легочной эмболией стала связь с острым тромбозом глубокой венозной системы и наружной вены, бедренных вен, подколенных вен, большеберцовых вен на фоне применения комбинированных оральных контрацептивов. 2022-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/33391 Title: Tromboembolism pulmonar subclinic în contextul patologiei cardiovasculare: caz clinic Authors: Țelinschii, Artemie; Medvedeva, Ecaterina; Sîrbu, Adelina; Ranga, Doina; Matcovschi, Sergiu; Corlăteanu, Olga; Talmaci, Cornelia; Caproş, Natalia Abstract: Scopul studiului a fost să prezentăm un caz de bărbat în vârstă de 72 de ani cu tromembolism pulmonar în contextul patologiei cardiovasculare. Acest raport de caz subliniază importanța diagnosticării și tratamentului precoce pentru a evita consecințe fatale. Identificarea tromboembolismului pulmonar în cazurile de patologie cardiovasculară poate fi complexă din cauza suprapunerii simptomatologiei, influenței tratamentului asupra testelor diagnostice și dificultăților de interpretare ale investigațiilor imagistice.; The aim of the study was to present a case of a 72-year-old man with pulmonary thromboembolism in the context of cardiovascular pathology. This case report highlights the importance of early diagnosis and treatment to prevent fatal outcomes. Identifying pulmonary thromboembolism in cases of cardiovascular pathology can be challenging due to overlapping symptoms, the influence of treatment on diagnostic tests, and difficulties in interpreting imaging investigations.; Целью исследования было представить случай 72-летнего мужчины с легочным тромбоэмболизмом на фоне сердечно-сосудистой патологии. Этот клинический случай подчеркивает важность ранней диагностики и лечения для предотвращения фатальных исходов. Выявление легочного тромбоэмболизма в случаях сердечно-сосудистой патологии может быть сложным из-за пересечения симптомов, влияния лечения на диагностические тесты и трудностей в интерпретации данных визуализации. 2024-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/33390 Title: Trombembolism pulmonar la femei in menopauză: prezentare de caz Authors: Ranga, Doina; Şveţ, Svetlana; Cealan, Andrei; Matcovschi, Sergiu; Sîrbu, Ion; Caproş, Hristiana; Talmaci, Cornelia; Caproş, Natalia Abstract: Studiul de față prezintă cazul unei paciente de 73 de ani, cu multiple comorbidități cardiovasculare. Particularitățile cazului prezentat sunt: simptome nespecifice și adresare tardivă cu evoluție dramatică, deși s-a instituit tratamentul complex, inclusiv anticoagulant. Studiile incluse în analiza literaturii au vizat următoarele: incidența și severitatea TEP la femei versus bărbați, rolul comorbidităților cu impact pe riscul de TEP, diferențele în utilizarea trombolizei.; This study presents the case of a 73-year-old female patient with multiple cardiovascular comorbidities. The case’s particularities include nonspecific symptoms, delayed presentation, and a dramatic outcome despite the implementation of complex treatment, including anticoagulation. The literature review focused on the following aspects: the incidence and severity of PE in women versus men, the role of comorbidities in influencing PE risk, and differences in thrombolysis usage. 2024-01-01T00:00:00Z