http://repository.usmf.md:80/handle/20.500.12710/822 2026-04-25T04:07:19Z http://repository.usmf.md:80/handle/20.500.12710/2002 Title: The influence of the tumoral cell proliferation rate in pituitary adenoma on expressing other factors with a prognostic role and therapeutic potential Authors: Melnic, Eugen Abstract: Background: This article describes the growth rate of pituitary adenomas, their invasion and potential recurrence. Some of them grow rapidly while others remain in a dormant condition for a long time. The recurrence rate is also very hard to forecast. The pituitary adenomas that initially reduced their proliferation rate now acquire a rapid one, producing aggressive recurrences. Materials and methods: Eighty two cases of pituitary adenomas were studied. The classification of human pituitary adenomas has been profoundly assisted by immunohistochemistry. Ki-67 antibody was used to assess the proliferative index of pituitary adenomas. Results: Acidophil type adenomas or acidophil cells areas within mixed pituitary adenomas had the highest proliferation rate. Chromophobe pituitary adenomas were Ki67 negative in 90%, as well as the ones that presented the basophilic cells. The pituitary adenomas with a trabecular growth pattern had the lowest rate of proliferation, in about 50% of the cases being zero. The heterogeneity expression of growth factors and corresponding receptors is dependent on hormonal profile of pituitary adenomas. Conclusion: The pituitary adenomas proliferation rate depends on the type of secreted hormone as well as on the hormonal associations met in some cases of pituitary adenomas. Description: Department of Morphopathology, Nicolae Testemitsanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova 2015-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/2000 Title: Monograph “The heterogeneity of histological types of breast cancer: sources, reasons and practical application”, the author: Veaceslav Fulga Authors: Melnic, Eugen Abstract: Breast cancer is the most common cancer in women worldwide. It is described as a group of heterogeneous diseases, different in clinical course, pathological aspects and therapeutic sensibility. Description: Morphopathology Department, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova 2016-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/1998 Title: Profilul imunohistichimic al adenoamelor hipofizare. Certitudini și controverse Authors: Melnic, Eugen; Foca, Ecaterina Abstract: Tumorile hipofizare sunt procese patologice la nivelul hipofizei, sunt hormonal active, cu localizare la baza creierului. Hipofiza, deși au dimensiuni reduse, are un rol foarte important în reglarea metabolismului și participă la maturarea organismului în general. Tumorile hipofizare reprezintă 10-25% din totalitatea tumorilor cu localizare intracerebrală, au o rata de creștere foarte lentă și nu au capacitatea de a metastaza. În pofi da faptului că sunt benigne din punct de vedere histologic au un efect biologic malign și din acest motiv necesită să fie calitativ diagnosticate. La ora actuală realizarea profi lului imunohistochimic permite diagnosticarea funcției secretorii a tumorii și prescrierea tratamentului personalizat. Pituitary tumors are hormonally active pituitary disease processes, localized at the base of the brain. Pituitary gland, although small, it has an important role in metabolism regulating and takes part in the maturation of body in general. Pituitary tumors represent 10-25% of all intracranial tumors, have a very slow growth rate does not have the ability to metastasize. Despite the fact that they are benign histologically they have a biological malignant effect and therefore need to be qualitatively diagnosed. Currently immunohistochemical profi ling permits to diagnose the tumor secretory function and prescribe personalized treatment. Опухоли гипофиза – это гормонально активные патологические процессы, локализованы у основания головного мозга. Гипофиз, хотя и небольших, играет важную роль в регуляции обмена веществ и участвует в созревании организма в целом. Опухоли гипофиза представляют собой 10-25% всех внутричерепных опухолей, имеют очень медленный темп роста не обладают способностью к метастазированию. Несмотря на то, что они являются гистологически доброкачественными, но имеют злокачественный биологический эффект и, следовательно, должны быть качественно диагноcтицированны. В настоящее время иммуногистохимическое профилирование дает возможность установить секреторную функцию опухоли и назначить персонализированное лечение. Description: Catedra Morfopatologie, IP USMF „Nicolae Testemiţanu” 2016-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/1999 Title: Corelația imuno-morfologică în adenoamele hipofizare Authors: Melnic, Eugen Abstract: Acest articol oferă o abordare practică în diagnosticul adenoamelor hipofi zare, care sunt trimise la anatomopatolog în momentul intervenției chirurgicale. Examenul inițial necesită colorație de rutină cu hematoxilina și eozina. Acestea sunt evaluate cu diferiți markeri imunohistochimici care sunt acum disponibili pentru a clasifi ca cu exactitate aceste patologii. Subclasifi cările complexe ale adenoamelor hipofi zare sunt recunoscute pentru a refl ecta caracteristicile clinice specifi ce și modifi cările genetice care permit tratamentul personalizat pentru pacienții cu tulburari pituitare. Cuvinte-cheie: Adenom, hipofi ză, imunohistochimie, markeri The immuno-morphological correlation in pituitary adenomas This review provides a practical approach to the diagnosis of pituitary specimens that are sent to the pathologist at the time of surgery. The initial examination requires routine haematoxylin and eosin staining. These are evaluated with several special stains and immunohistochemical markers that are now available to accurately classify these pathologies. The complex subclassifi cation of pituitary adenomas is now recognized to refl ect specifi c clinical features and genetic changes that predict targeted treatments for patients with pituitary disorders. Иммуно-морфологическая взаимосвязь в аденомах гипофиза В данной статье представлен практический подход к диагностике аденом гипофиза. Первоначально требуется обычное окрашивание гематоксилином и эозином. Далее ткань обрабатывается различными иммуногистохимическими маркерами, которые позволяют точно классифицировать эти патологии. Комплексная классификация аденомы гипофиза отражает конкретные клинические особенности и генетические изменения, которые позволяют персонализированное лечение пациентов с расстройствами гипофиза. Ключевые слова: аденома, гипофиз, иммуногистохимические маркеры Description: IP USMF „Nicolae Testemiţanu”, Catedra Morfopatologie 2016-01-01T00:00:00Z