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Curierul medical. April 2016, Vol. 59, No 2

Fri, 01 Jan 2016 00:00:00 GMT

Title: Curierul medical. April 2016, Vol. 59, No 2 Abstract: From its debut in 1958, the journal has striven to support the interests of Moldovan medicine concerning the new concepts of its development. The Editorial Board warmly welcomes both the readers of and the authors for the journal, all those who are enthusiastic in searching the new and more effective ways of solving numerous medical problems. We hope that those who want to make their contribution to the science of medicine will find our journal helpful and encouraging. The journal is accredited by the National Council for Accreditation and Attestation. The journal publishes official papers, scientific articles, editorials, clinical studies and cases, lectures, methodological guides, reviews, brief reports, and correspondence. The journal welcomes articles in English, Romanian and Russian. The journal editorial policy provides the prompt publication of papers within 12 weeks after receiving them.; De la prima apariţie în 1958, revista susţine şi dezvoltă noile idei în domeniul medicinii, în Republica Moldova. Colegiul de redacţie agrează cu multă consideraţie atât cititorii cât şi autorii articolelor, pe toţi acei care cu mult entuziasm caută noi şi mult mai efective metode de soluţionare a multiplelor probleme ale medicinii. Sperăm, că toţi acei care doresc să-şi aducă aportul la dezvoltarea ştiinţelor medicale, vor găsi revista noastră utilă şi atractivă. Revista este acreditată de către Consiliul Naţional de Acreditare şi Atestare. Revista publică comunicări oficiale şi, totodată, sunt editate diverse publicaţii, inclusiv independente: articole ştiinţifice, editoriale, cercetări şi prezentări de cazuri clinice, prelegeri, îndrumări metodice, articole de sinteză, relatări scurte, corespondenţe şi recenzii. Revista publică articole în limba engleză, română şi rusă. Politica de editare a revistei prevede examinarea operativă şi publicarea articolelor timp de 12 săptămâni după înaintare.; С первого дня своего выпуска в 1958 году журнал стремится поддерживать и развивать новые идеи в области медицины в Молдове. Редакционная коллегия всегда рада как читателям, так и авторам статей, всем тем, кто с энтузиазмом ищет новые, более эффективные способы решения многочисленных задач медицины. Мы надеемся, что все те, кто хотят внести свой вклад в медицинскую науку, найдут наш журнал полезным и вдохновляющим. Журнал аккредитован Высшей Аттестационной Комиссией Республики Молдова. В журнале печатаются официальные материалы, научные статьи, наблюдения из клинической практики, обобщающие статьи, краткие сообщения, методические указания, рецензии и корреспонденция. В журнале публикуются статьи на английском, румынском и русском языках. Издательская политика журнала предусматривает оперативное рассмотрение и публикацию статей в среднем в течение 12 недель после поступления. Description: Fondatori: Ministerul Sănătăţii al Republicii Moldova, Universitatea de Stat de Medicină şi Farmacie “Nicolae Testemiţanu”

Vasilii Chekurin – 125 years since the date of the birth

Fri, 01 Jan 2016 00:00:00 GMT

Title: Vasilii Chekurin – 125 years since the date of the birth Authors: Ababii, Ion; Cabac, Vasile; Maniuc, Mihai; Sandu, Alexandru

Influence of new Schiff bases and their combinations with 3d metals on the glutathione and thiol-disulfide metabolism in the liver in physiological conditions

Fri, 01 Jan 2016 00:00:00 GMT

Title: Influence of new Schiff bases and their combinations with 3d metals on the glutathione and thiol-disulfide metabolism in the liver in physiological conditions Authors: Andronache, Lilia Abstract: Background: Glutathione and glutathione metabolism enzymes are essential for the normal functioning of cells and tissues and maintenance of body homeostasis. The aim of our study was to investigate the influence of the new Schiff bases, and their combinations with 3d metals, on the glutathione metabolism in the liver in physiological conditions. Material and methods: An experimental study of laboratory animals (rats) was performed. New local biologically active compounds (BAC) – CMD-4, CMD-8 and CMJ-23, were injected to healthy rats for 14 days. The content of glutathione (total, reduced and oxidized) and the activity of glutathione reductase (GR), glutathione peroxidase (GPO), glutathione-S-transferase (GST) and glutaredoxin (GRX) were determined in the liver homogenates. results: All tested BAC statistically significant decreased the level of reduced and total glutathione (about 20-30%), and GMJ-23 also reduced the oxidized glutathione in the liver (-48%, p<0.05). Influence on the activity of enzymes of glutathione metabolism was more ambiguous. Administration of CMD-4, CMD-8 and CMJ-23 did not produce conclusive changes of the enzyme activity of the glutathione metabolism, and their induction had only tendency of GR, GST and GRX activity decrease, while CMT-28 and CMT-67 preferentially modulated the activity of enzymes. conclusions: Local BAC exerts an individual influence on the glutathione metabolism in physiological conditions, which may be used for a particular regulation of the processes according to the cell needs.

S100 protein expression in pituitary adenomas

Fri, 01 Jan 2016 00:00:00 GMT

Title: S100 protein expression in pituitary adenomas Authors: Melnic, Eugen Abstract: Background: The predicting of pituitary tumor behavior remains one of the most incurable medical problems. One of the causes is poor correlation between the morphology of pituitary tumors and their clinical aggressiveness. Material and methods: 96 cases included in our study have been microscopically investigated on specimens colored with eosin haematoxylin by three experienced pathologists according to WHO recommendations. Out of these ten cases were represented by normal pituitary tissue to make it possible to compare the typical pituitary morphology with the microscopic appearance of various types of pituitary adenomas. results: In both the normal pituitary gland and in pituitary adenomas, endothelial cells presenting a nuclear expression for S100 were occasionally observed. The percentage of positive cases for protein S100 was 66.12% from the total number of cases. Amongst these, 39.02% presented a compact growth pattern, 39.04% were of papillary type, 9.75% presented a trabecular growth pattern, 4.87% spindle-shaped and 7.31% were of alveolar type. Papillary type pituitary adenomas registered the highest intensity of expression for protein S100 in tumor cells. The acidophilic cells were present in a percentage of 34.2% of cases. Pituitary adenomas with basophilic cells represented a percentage of 26.8% of positive cases for protein S100, and, for 39% of cases the chromofobe component was present forming pure chromofobe pituitary adenomas or mixed chromofobe-acidophilic/basophilic pituitary adenomas. conclusions: Protein S100 expressions in tumor cells is implicated in the pathogenesis of the growth hormone and prolactin secreting pituitary adenomas, the mechanisms of activation being nowadays incompletely studied. Through analogy with the observations obtained in other tumor types, it is possible that S100 pituitary adenomas to represent a group of pituitary adenomas with an aggressive behavior and a high capacity of invasion and recurrence, aspects that represent an unfavorable prognostic factor.