http://repository.usmf.md:80/handle/20.500.12710/12300 Issue dedicated to the 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020) Sun, 12 Apr 2026 22:34:03 GMT 2026-04-12T22:34:03Z http://repository.usmf.md:80/handle/20.500.12710/16913 Title: The Moldovan Medical Journal. November 2020, Vol. 63, No 5 Abstract: The Moldovan Medical Journal is an international scientific double-blind peer-reviewed periodical edition, 4 per year, of the Scientific Medical Association of the Republic of Moldova designed for specialists in the areas of medicine, dentistry, pharmacy, social medicine, and public health. From its debut, the journal has striven to support the interests of Moldovan medicine concerning the new concepts of its development. The Editorial Board warmly welcomes both the readers of and the authors of the journal, all those who are enthusiastic about searching for new and more effective ways of solving numerous medical problems. We hope that those who want to make their contribution to the science of medicine will find our journal helpful and encouraging. Description: 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020) Wed, 01 Jan 2020 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/16913 2020-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/12330 Title: Precancerous gastric lesions: pathophysiology and symptomatology Authors: Botezatu, Adriana; Bodrug, Nicolae; Istrate, Viorel Abstract: Background: Independent risk factors for chronic atrophic gastritis, gastric intestinal metaplasia and gastric cancer are: Helicobacter pylori infection (especially virulent CagA strains), genetic factors (advanced age, reflecting the duration of Helicobacter pylori infection, male gender, family history of gastric cancer in first-degree relatives), gastric ulcer, biliary reflux, acute or chronic gastric inflammation, smoking, alcohol consumption, prolonged use of proton pump inhibitors or non-steroidal anti-inflammatory drugs, diet low in fruits, vegetables and vitamin C, excessive salt intake and consumption of canned foods with salt). Helicobacter pylori infection and inflammatory cells induce the expression of inducible nitric oxide synthase in the gastroduodenal mucosa, which causes various clinical lesions (duodenal ulcer, gastric ulcer and chronic gastritis without ulcer). Another important condition associated with Helicobacter pylori infection is gastric cancer. Overproduction of nitric oxide, through inducible nitric oxide synthase and oxidative stress, is a genotoxic and mutagenic metabolism which plays a crucial role in the process of gastric carcinogenesis. Conclusions: Chronic atrophic gastritis is considered a multifaceted condition because it can manifest itself through a variable spectrum of nonspecific gastric and extra-gastric symptoms, with an overlap of the clinical features of the two entities of chronic atrophic gastritis – autoimmune and associated with Helicobacter pylori infection. Thus, in contrast to the classic perception of a silent condition, patients with chronic atrophic gastritis report a wide range of gastrointestinal symptoms, ranging from dyspeptic symptoms to those of gastroesophageal reflux. Description: Department of Internal Medicine, Discipline of Geriatrics and Occupational Diseases Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova, Medical Center ”Excellence”, Chisinau, the Republic of Moldova, The 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020) Wed, 01 Jan 2020 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/12330 2020-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/12329 Title: Applicability of next generation genetic testing in epilepsy through whole exome sequencing Authors: Catereniuc, Daniela; Chelban, Viorica; Groppa, Stanislav Abstract: Background: Epilepsy affects around 1% of the general population. With already acknowledged strong genetic contributions, >50% of epilepsy cases still remain undiagnosed. This is primordially due to the multifactorial condition of epilepsy that makes it a challenge to select the optimal genetic test for each specific case. Recently, next-generation sequencing (NGS) led to massive gene discovery, including epilepsy that also imposed serious financial burdens on healthcare systems. This study review highlights the progress in the field of epilepsy genetics and argues on how the genetic architecture of common epilepsies is progressively being unraveled. Since the 1995 finding of CHRNA4 mutation, more than 500 genes were estimated to play a significant role in epilepsy. To date, the majority of diagnostic genetic testing is conducted in the pediatric population, while the utility of such testing is less well understood in adults with epilepsy. A broad range in the diagnostic rate of NGS, especially of the Whole Exome Sequencing (WES), in epilepsy has been described. However, NGS introduces new challenges, yet to be resolved. Conclusions: Epilepsy’s genetic background is nowadays undeniable; however, the complexity of this condition makes it difficult to be solved. WES has increasingly been used to uncover the role of the coding genetic material in the human genome and is nowadays considered one of the most costeffective genetic tests for epilepsy, being a prerequisite for personalized treatment approaches and for reducing the epilepsy patient’s “diagnostic odyssey”. Description: Laboratory of Neurobiology and Medical Genetics, Department of Neurology No 2 Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova, Department of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, Great Britain, The 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020) Wed, 01 Jan 2020 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/12329 2020-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/12328 Title: Acute transverse myelitis in a HIV-positive patient with COVID-19 Authors: Nemtan, Victor; Hacina, Evghenia; Topciu, Galina; Manole, Elena; Lisnic, Vitalie; Thurnher, Majda; Kummer, Rüdiger von Abstract: Background: Immunocompromised status keeps on being a challenge for a physician, especially in the context of the coronavirus disease – 19 (COVID-19) pandemic. The predominant clinical presentations are related to the respiratory system, but neurological manifestations are recognized increasingly. Cases of myelitis associated with the new coronavirus infection have already been published, but no cases of HIV-positive patients with myelitis and COVID-19 have been reported yet. Material and methods: This study described a clinical case of a human-immunodeficiency virus (HIV) – positive patient, who developed an acute transverse myelitis with confirmed SARS-CoV-2 infection. Results: Magnetic Resonance Imaging examination showed longitudinally extensive spinal cord abnormality, and laboratory tests confirmed SARS-CoV-2 infection. The patient responded to methylprednisolone pulse therapy, followed by oral corticosteroids and therapeutic plasma exchange. Conclusions: Continuing pandemic and the expectation that a large part of the world population will be infected suggest that the number of patients with neurological manifestations could become large. Curious neurologic constellations can appear which complicate the diagnostic process and treatment in certain patients. Description: Medical Department of Security and Intelligence Service of the Republic of Moldova Chisinau, the Republic of Moldova, Department of Neurology No 1, Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova, Department of Biomedical Imaging and Image-Guided Therapy, Medical University Vienna, Austria, Institute of Diagnostic and Interventional Neuroradiology, Universitätsklinikum Dresden, Germany, The 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020) Wed, 01 Jan 2020 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/12328 2020-01-01T00:00:00Z