http://repository.usmf.md:80/handle/20.500.12710/19346 The Annual Scientific Conference of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova on the occasion of the 76 years of activity: Research in biomedicine and health quality, excellence and performance, 20-22 October 2021 Sun, 12 Apr 2026 09:13:33 GMT 2026-04-12T09:13:33Z http://repository.usmf.md:80/handle/20.500.12710/19426 Title: Erythrocytic antioxidant system in the administration of new coordination compounds thiosemicarbazide derivatives Authors: Pantea, Valeriana; Gamaniuc, Marina; Popa, Veaceslav Abstract: Background: Currently, there is a growing interest in new local coordination compounds (CC), which demonstrated antitumor properties, but their influence on the erythrocyte antioxidant system has not been studied. The aim of the study: to study the effects of CC, thiosemicarbazide derivatives –TIA-160, CMT-67 and CMJ-33 on indices of the antioxidant system indicators in erythrocytes peripheral blood in vivo experiments. Material and methods: The action of CC on superoxide dismutase, catalase, total antioxidant capacity was evaluated on a group of 34 white rats, randomly divided into 4 groups: the first control group was injected subcutaneously with saline. The other groups (2 – TIA-160, 3 – CMT-67 and 4 – CMJ-33) were given subcutaneously 3 times a week for 30 days, 0.1µM / kg CC. Results: It was established that the TIA-160 compound demonstrated the highest capacity to induce the expression of erythrocyte catalase that exceeded the control level of 1.8, which did not correlate with the enzymatic superoxide dismutase (SOD) activity. Thus, this study showed that there are differences in the mechanisms of action of thiosemicarbazone derivatives. Conclusions: The influence of tested CC on the indices of the antioxidant system is selective. This selectivity may be the base to their strong selective antiproliferative and cytotoxic action on tumor cells, but not on healthy ones. Description: Laboratory of Biochemistry, Department of Biochemistry and Clinical Biochemistry Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova Fri, 01 Jan 2021 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/19426 2021-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/19425 Title: The role of boron in the functioning of the osteoarticular system Authors: Racu, Maria-Victoria; Scorei, Ion Romulus; Pinzaru, Iurie Abstract: Background: Boron was classified by the World Health Organization as ‘possible essential elements for human health’. It can be found in different forms in the environment, has beneficial effects on bones and its deprivation can impair calcium and magnesium metabolism and bone development, their health and maintenance. Dietary boron supplementation can help prevent and manage degenerative and inflammatory bones and articular diseases, such as arthritis, osteoarthritis, rheumatoid arthritis and osteoporosis. Relevant articles were identified in PubMed, Google Scholar, ProQuest, and Scopus databases published until June 2021, describing the role of boron in the functioning of the osteoarticular system. Conclusions: From organic and inorganic boron forms that can enter the human body, organic plant based boron compounds are highly bioavailable. In the functioning of the osteoarticular system boron acts by regulation of calcium and magnesium metabolism, enhancing the vitamin D activation process and influencing serum steroid hormone levels. A boron intake equal to or higher than 3 mg per day can help prevent/or correct arthritis, osteoporosis and osteoarthritis. Calcium fructoborate can reduce pain, joint discomfort and increase endogenous vitamin D level in patients with osteoarthritis. Boron may play a role in pathophysiology of rheumatoid arthritis and its severity and a supplementation with boron element may be useful. Description: National Agency for Public Health, Chisinau, the Republic of Moldova, BioBoron Research Institute, Craiova, Romania Fri, 01 Jan 2021 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/19425 2021-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/19424 Title: The Moldovan Medical Journal. September 2021, Vol. 64, No 5 Abstract: The Moldovan Medical Journal is an international scientific double-blind peer-reviewed periodical edition, 4 per year, of the Scientific Medical Association of the Republic of Moldova designed for specialists in the areas of medicine, dentistry, pharmacy, social medicine, and public health. From its debut, the journal has striven to support the interests of Moldovan medicine concerning the new concepts of its development. The Editorial Board warmly welcomes both the readers of and the authors of the journal, all those who are enthusiastic about searching for new and more effective ways of solving numerous medical problems. We hope that those who want to make their contribution to the science of medicine will find our journal helpful and encouraging. Description: The Annual Scientific Conference of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova on the occasion of the 76 years of activity: Research in biomedicine and health quality, excellence and performance, 20-22 October 2021 Fri, 01 Jan 2021 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/19424 2021-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/19423 Title: First manifestation and evolution of early left ventricular dysfunction in children with Duchenne muscular dystrophy Authors: Rodoman, Iulia; Dorif, Alexandr; Palii, Ina; Sacara, Victoria Abstract: Background: Standard pediatric cardiology examinations and echocardiography fail to discover when the cardiomyopathy will occur in patient with Duchenne muscular dystrophy (DMD). Noninvasive markers are needed to fill this gap. Material and methods: This cohort study included a total number of 30 children (21 children (70%) with DMD and 9 (30%) healthy children. Blood samples were used for biochemical (level of creatine kinase, creatine kinase-MB, lactate dehydrogenase) and miRNA (presence of miR133a 3p, miR133b 3p, miR206 3p, miR208a 3p, miR208b 3p) analysis. All patients underwent partial conventional echocardiography ECOCG and Speckle Tracking. Results: The children in the working group presented compared to healthy children: FCC values increased by 15 (71%) vs 2 (22%), high levels of CK, CK-MB, LDH, which is characteristic for the disease and reflects its stage. Also, there is a decrease in systolic function indicators in the working group: mean FE 59 ± 3.8 %, and GLS: -16.2 ± 3.1%. MiRNA analyses confirmed the presence of miR133a 3p, miR133b 3p, miR206 3p, miR208a 3p, miR208b 3p in both working and control group. Conclusions: For the first time in the Republic of Moldova, we developed and adapted protocols for RNA extraction from human blood, performing screening of specific miRNA in the serum of patients with DMD and healthy children. Also, altered LV strain notwithstanding a normal or mildly modified LVEF represents an essential viewpoint for prospective pediatric drug trials in DMD-related cardiomyopathy prevention. Description: Department of Pediatrics, Nicolae Testemitanu State University of Medicine and Pharmacy, Cardiology Unit, Human Molecular Genetics Laboratory, Institute of Mother and Child Chisinau, the Republic of Moldova Fri, 01 Jan 2021 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/19423 2021-01-01T00:00:00Z