http://repository.usmf.md:80/handle/20.500.12710/20359 Tue, 07 Apr 2026 14:37:13 GMT 2026-04-07T14:37:13Z http://repository.usmf.md:80/handle/20.500.12710/21565 Title: One Health & Risk Management. 2022, Vol. 3, No. 2 Abstract: One Health & Risk Management is a biannual scientific journal for specialists in medical and biological sciences, which was founded in 2019 within the Moldavian Biosafety and Biosecurity Association (MDBBA). The journal accepts submissions in Romanian, English, French and Russian, in accordance with current international standards and guidelines. The Journal policy is aligned with the new concepts of international organizations (WHO, OIE FAO, etc.), such as One Health Approach, enclosed within a cooperative, multisectoral, transdisciplinary, national and international framework. The current state of the contemporary world in terms of depth and dynamics of changes, as well as the accelerated rate of research and innovation on evidence-based risk management, generate a progressive growth in the amount of medical and biological data. Therefore, One Health & Risk Management Journal will support and publish manuscripts based on scientific evidence on human, animal and environmental health. The priority for acceptance would be given to those articles which report study results on identification of specific hazards and risk assessment associated with these hazards, development and analysis of potential risk management options, as well as selection and implementation of a specific monitoring and evaluation strategy used for risk management. The rigorous review process (double-blind peer review) will involve professionals from various scientific fields, who comply with the international ethical guidelines for scientific publications. One Health & Risk Management magazine will increase its visibility by exchanging articles with other relevant publications and collaborating with similar national and international organizations, as well as via its website, which includes the recently published articles, providing the opportunity to get real-time information (Free Open Access). The editorial board of the magazine brings together outstanding personalities, both from the country and abroad, who help to maintain the journal to the highest scientific standards. Sat, 01 Jan 2022 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/21565 2022-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/20386 Title: Academicianul Valeriu Rudic–savant, microbiolog şi inventator remarcabil Sat, 01 Jan 2022 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/20386 2022-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/20385 Title: Paniculita mezenterică: aspecte terapeutice prin prisma unui caz clinic Authors: Gorea, Alexandru; Stoica, Mihaela; Scorpan, Anatolie; Sarbu, Oxana; Istrati, Valeriu Abstract: Introduction. Mesenteric panniculitis is a rare medical condition. Its incidence is between 0.16%-3.4%. The small number of cases of PM and the ignorance of its causes, pathogenesis and treatment significantly affect the prognosis of the disease. Materials and methods. An analysis of the literature and the case of patient R, aged 47, who is admitted in the Public Medico-Sanitary Institution, is presented. Results. Accusations: periumbilical pain, marked physical asthenia and significant weight loss. In the left abdominal flank, a tumor of 9.0x14.0 cm was palpated, soft as consistensy, elastic, sensitive to palpation, fixed to the deep planes. Clinical examination and abdominal CT examination led to the diagnosis of mesenteric panniculitis. Drug treatment with NSAIDs and corticosteroids had a favorable outcome, confirming the autoimmune etiology of PM. Conclusions. Mesenteric panniculitis is a rare pathology and its diagnosis is difficult to establish. The drug treatment with NSAIDs and corticosteroids can lead to good and lasting clinical results.; Introducere. Paniculita mezenterică (PM) reprezintă o patologie medicală rară. Incidența acestei maladii variază între 0,16%-3,4%. Numărul mic de cazuri atestat, etiologia incertă, necunoașterea exhaustivă a patogeniei și a tratamentului PM, afectează semnificativ prognosticul bolii în cauză. Materiale și metode. Se prezintă o analiză a literaturii și cazul pacientului R, de 47 de ani, internat în Instituția Medico-Sanitară Publică. Rezultate. Acuze: dureri periombilicale, astenie fizică accentuată și pierdere ponderală semnificativă. În flancul abdominal stâng, se palpează o formațiune tumorală de 9,0x14,0 cm, de consistență moale, elastică, sensibilă la palpare, fixată de planurile profunde. Examenul clinic obiectiv și examinarea CT abdominale au condus către diagnosticul de paniculită mezenterică. Tratamentul medicamentos cu AINS și corticosteroizi a înregistrat un rezultat favorabil, fapt care confirmă etiologia autoimună a PM. Concluzii. Paniculita mezenteriacă este o patologie rară, al cărei diagnostic este greu de stabilit. Tratamentul medicamentos AINS și corticosteroizi a contribit la înregistrarea unor rezultate clinice favorabile și de durată. Sat, 01 Jan 2022 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/20385 2022-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/20383 Title: Modification of oxidative stress indices in cultures of pathogenic microorganisms under the influence of novel chemical compounds Authors: Lozan-Tirsu, Carolina; Zariciuc, Elena Abstract: Introduction. It is known that excessive formation of hydrogen peroxide in the microbial cultures under the action of chemical compounds with antibacterial effects is the first stage in the formation of oxidative stress. Thus, it became appropriate to conduct a study that would make it possible to control the level of oxidative stress induced by chemical compounds in cultures of pathogenic microorganisms. Material and methods. The objects of the in vitro study were Cu(II) coordination compounds; Co(II), Zn(II) and aromatic propenones synthesized at the Department of Inorganic Chemistry of the State University of Moldova. Antimicrobial activity was tested on 5 reference strains. The level of oxidative stress was controlled using the hydrogen peroxide test, and the level of lipid peroxidation was determined indirectly by monitoring the product of peroxidation, namely the malondialdehyde. Results. Under the action of new chemical compounds with antimicrobial properties on reference cultures of Staphylococcus aureus ATCC 25923, Bacillus cereus ГИСК 8035, Escherichia coli ATCC 25922, Shigella sonnei ATCC 25931 and Salmonella enterica (Salmonella abony ГИСК 03/03y) in cultures that create a state of oxidative stress, confirmed by the accumulation of hydrogen peroxide and lipid peroxidation products. Conclusions. Thus, the process of lipid peroxidation, which follows the pattern of chain reactions, is one of the reactions that lead to the death of cell culture. The level of hydrogen peroxide formed under the action of the tested compounds was also monitored.; Introducere. Este cunoscut faptul că formarea excesivă a peroxidului de hidrogen în culturile de microorganisme, sub influența compușilor chimici cu efecte antibacteriene, constituie primul pas în generarea stresului oxidativ. Astfel, a devenit oportună realizarea unui studiu care ar monitoriza nivelul stresului oxidativ indus de către compușii chimici în culturile de microorganisme patogene. Material și metode. În calitate de obiecte de studiu in vitro au servit compușii coordinativi ai Cu (II); Co (II), Zn (II) și propenonele aromatice, sintetizate la Catedra de chimie anorganică de la Universitatea de Stat din Moldova. Efectele antimicrobiene au fost testate pe 5 tulpini de referință. S-a monitorizat nivelul stresului oxidative prin testul de determinare a peroxidului de hidrogen și a fost stabilit indirect nivelul de peroxidare a lipidelor, prin monitorizarea produsului peroxidării–dialdehida malonică. Rezultate. Sub acțiunea compușilor chimici noi cu proprietăți antimicrobiene asupra culturilor de referință Staphylococcus aureus ATCC 25923, Bacillus cereus ГИСК8035, Escherichia coliATCC 25922, Shigella sonnei ATCC 25931 şi Salmonella enterica (Salmonella abony ГИСК03/03y) în culturi se creează o stare de stres oxidativ, confirmat prin acumularea peroxidului de hidrogen și a produselor peroxidării lipidelor. Concluzii. Astfel, procesul de peroxidare a lipidelor, care decurge după modelul reacțiilor în lanț, este una dintre reacțiile care conduc la moartea culturii celulare. De asemenea, a fost monitorizat și nivelul peroxidului de hidrogen format sub influența compușilor testați. Sat, 01 Jan 2022 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/20383 2022-01-01T00:00:00Z