http://repository.usmf.md:80/handle/20.500.12710/21725 Sat, 18 Apr 2026 15:25:46 GMT 2026-04-18T15:25:46Z http://repository.usmf.md:80/handle/20.500.12710/21736 Title: The Moldovan Medical Journal. August 2022, Vol. 65, No 1 Abstract: The Moldovan Medical Journal is an international scientific double-blind peer-reviewed periodical edition, 4 per year, of the Scientific Medical Association of the Republic of Moldova designed for specialists in the areas of medicine, dentistry, pharmacy, social medicine, and public health. From its debut, the journal has striven to support the interests of Moldovan medicine concerning the new concepts of its development. The Editorial Board warmly welcomes both the readers of and the authors of the journal, all those who are enthusiastic about searching for new and more effective ways of solving numerous medical problems. We hope that those who want to make their contribution to the science of medicine will find our journal helpful and encouraging. Sat, 01 Jan 2022 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/21736 2022-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/21735 Title: Phenotypic polymorphism in Wilson’s disease – between genetics and epigenetics Authors: Cumpata, Veronica Abstract: Background: Wilson’s disease is a rare, autosomal recessive genetic disorder that affects the biliary excretion of copper and its toxic accumulation in various tissues, especially the liver and brain. It is widespread throughout the world, with a high prevalence in socio-culturally isolated communities. The course of the disease and the age of onset depend on the site of mutation in the gene and the degree of functional impairment of the ATP7B protein. The presence of the compound heterozygous patient complicates the comparative genetic and clinical evaluation. Therefore, it is necessary to analyze Wilson’s variants in both the homozygous and the compound-heterozygous conditions to better understand the genotype-phenotype correlations and the incomplete penetrance observed in this disorder. Outlining clear phenotype-genotype associations is difficult due to a large number of mutations and different clinical presentations, but the involvement of epigenetic factors, modifying genes, environmental and lifestyle factors could explain the differences in evolution and onset in members of the same family and not only. Conclusions: Wilson’s disease is a genetically and clinically complex disorder. Although the results of genotype-phenotype correlation studies are not well defined, and in some cases are completely contradictory, some peculiarities related to the age of onset, sex, clinical phenotype, and the evolution of the disease have been highlighted. The interaction between genetic mutations and epigenetic factors may explain the phenotypic variability, but needs further study. Sat, 01 Jan 2022 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/21735 2022-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/21734 Title: Low-grade systemic inflammation in subclinical hypothyroidism Authors: Vudu, Stela; Krishna, Gouri Durga Abstract: Background: Hypothyroidism is the deficiency in the production of thyroid hormones to meet the requirements of peripheral tissues. Subclinical hypothyroidism (SCH) is defined biochemically as normal serum free thyroxin concentration in the presence of an elevated serum thyroid-stimulating hormone (TSH) concentration. SCH may be associated with low-grade systemic inflammation (increased high sensitivity-C reactive protein (hs-CRP), one possible explanation may be that TSH in adipocytes promotes the release of interleukin-6 (IL-6). Studies have confirmed inflammatory biomarkers like hs-CRP and IL-6 to be a predictor of cardiovascular (CV) events. However, the treatment of SCH remains subject to debate. Conclusions: It is increasingly evident that SCH has prognostic values and crucial clinical effects, which leads to the view of SCH not being a compensated biochemical change sensu strictu. Even a modest but consistent fluctuation in the circulating thyroid hormone levels can create a response from the human heart. Well-timed treatment should be considered as a precaution to avoid the unfavourable CV diseases. The inflammatory biomarkers, namely CRP and IL-6 are exceptionally robust markers of cardiovascular risk. Thus, using these biomarkers may be helpful in assessing the cardiovascular risk in patients with subclinical hypothyroidism. Sat, 01 Jan 2022 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/21734 2022-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/21733 Title: Overview on possible causes of COVID-19 Authors: Draguta, Ilarion Abstract: Background: The infection with the new coronavirus SARS-CoV-2 has caused a large number of cases of disease and death worldwide. Identifying the source of COVID-19 is an important issue though still unresolved. The analysis of the literature on highlighting possible sources of the SARS-CoV-2 virus was carried out. Conclusions: The COVID-19 pandemic is occurring on the underlying imminent global ecological catastrophe as a result of the anthropogenic activity. Therefore, it can be stated that Homo Sapiens in the context of the interaction with the biosphere is a maladaptive species. According to the literature, the species’ adaptive responses to environmental changes are due to endogenous retroviruses. The latter act as evolutionary factors. Possible pandemic COVID-19 is not a separate epidemic process caused by the penetration of a new virus into human populations, but rather is one of the manifestations of a more complex natural phenomenon – an evolutionary process under the guise of an infectious one. In terms of evolution, COVID-19 plays the role of a biosphere factor that seeks to help a relatively new species to adapt to the general conditions of survival in a symbiotic relationship with other living organisms. Sat, 01 Jan 2022 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/21733 2022-01-01T00:00:00Z