http://repository.usmf.md:80/handle/20.500.12710/30066 Mon, 13 Apr 2026 13:38:04 GMT 2026-04-13T13:38:04Z http://repository.usmf.md:80/handle/20.500.12710/30079 Title: Unusual presentation of MALT lymphoma. A case report Authors: Tcaciuc, Eugen; Olaru-Stăvilă, Cătălina; Tcaciuc, Angela; Antoci, Lilian; Cernat, Mircea; Surlari, Margareta Abstract: Introduction. MALT lymphoma is the most common type of extranodal non-Hodgkin lymphoma. In two-thirds of cases, it originates in the stomach and is strongly associated with Helicobacter pylori infection. It presents a complex clinical picture, that can resemble multiple conditions, and typically follows a benign course. Clinical case presentation. This report discusses an uncommon case of a 52-year-old female who presented to the oncologist with insignificant weight loss, episodes of melena and fatigue. The disease started in 2018 with upper gastrointestinal bleeding from a gastric ulcer caused by H. pylori, which was later eradicated. The patient underwent multiple upper endoscopies over the years, with no evidence of malignancy. During the most recent investigation, an ulcerated mass of about 20 mm with infiltration of the adjacent mucosa was found. The biochemical and serological examination was within normal values. Abdominal computed tomography revealed unexplained perigastric and intestinal lymphadenopathy. The patient underwent total gastrectomy and lymph node dissection due to suspected gastric cancer. Histological and immunohistochemical examinations confirmed advanced MALT lymphoma with tumour cells positive for cluster of differentiation 45, 20 (CD45, CD20) and B-cell lymphoma 2 (BCL2). Given the advanced stage of the disease, adjuvant polychemotherapy was also administered, and the patient’s condition improved significantly. Conclusions. MALT lymphoma is a rare condition that requires close attention and a high index of suspicion, even in unusual cases like the one presented. Endoscopic examination performed by an experienced specialist, accompanied by proper biopsy and a multidisciplinary team approach increases the survival rate of patients. Mon, 01 Jan 2024 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/30079 2024-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/30078 Title: A case report of primary hepatic amyloidosis manifesting as severe cholestasis and acute liver failure Authors: Tcaciuc, Eugen; Berliba, Elina; Bugor, Kalina; Pretula, Ruslan; Olaru-Stăvilă, Cătălina; Bădărău, Ana Maria Abstract: Introduction. Hepatic amyloidosis is characterized by the deposition of fibrillar amyloid proteins, which result from light chain amyloidosis (AL) immunoglobulin fragments, in the extracellular space and the vessel walls of the liver. A case of primary hepatic amyloidosis without evidence of a primary or secondary cause of amyloid deposition is rare. This case was unique to the Republic of Moldova, presenting a diagnostic and therapeutic challenge for clinicians. Because the liver is rarely affected, this pathology remains underdiagnosed and is associated with a reserved prognosis. Clinical case presentation. An unusual case of primary hepatic amyloidosis is reported in a previously asymptomatic 59-year-old woman who presented at admission with peripheral edema, ascites, and hepatomegaly. Biochemical tests revealed severe cholestasis with normal bilirubin levels and acute liver failure. Liver damage caused by viral hepatitis or autoimmune diseases was excluded. A percutaneous bone marrow biopsy was normal, and Bence Jones protein was negative, indicating no evidence of primary amyloidosis. The definitive diagnosis was based on liver biopsy, which revealed apple green birefringence on polarizing microscopy after positive Congo red staining. Conclusions. The reported case highlights the need to differentiate between infiltrative diseases, such as amyloidosis, when a patient presents with rapidly progressive severe cholestasis and acute liver failure. Future studies should focus on the availability of specific therapies for primary amyloidosis to improve the survival rate of these patients. Mon, 01 Jan 2024 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/30078 2024-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/30077 Title: Mechanisms of niacin skin test pathogenesis in patients at clinical high risk for psychosis and schizophrenia Authors: Nastas, Igor; Boronin, Larisa Abstract: Introduction. Elevated or imbalanced levels of markers of oxidative stress and inflammation are often observed in various somatic pathologies and mental disorders, including schizophrenia. Purpose of the study. This study aims to investigate the mechanisms of pathogenesis and the evidence supporting the use of niacin skin and oral tests in patients with schizophrenia. Materials and methods. A literature review was conducted on the specific reactions to the niacin skin or oral test in patients with schizophrenia, first-episode psychosis, and those at clinical high risk for psychosis (CHR-P). Evidence-based data up to and including 2024 were reviewed, with 48 literary sources selected. Results. An attenuated niacin-induced flush, coupled with low vitamin B3 levels, an imbalance in the Redox-Ratio and omega-3/omega-6 fatty acids, and elevated phospholipase A2 levels, are the main evidence-based findings associated with schizophrenia. Conclusions. The niacin skin and oral tests in patients with schizophrenia and those at high risk for psychosis are characterized by an abnormal response to niacin. Additional markers may further validate positive test results for niacin. Mon, 01 Jan 2024 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/30077 2024-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/30076 Title: Parasitic infestations and their influence on joint inflammation Authors: Grosu, Maia; Groppa, Liliana; Plăcintă, Gheorghe; Pântea, Victor; Russu, Eugeniu Abstract: Objective. The objective of this study was to conduct a bibliographic analysis of current data regarding the impact of parasitic infestations on immune status and the progression of osteoarticular diseases within the context of parasitic infections. Material and methods. This was a qualitative analytical study presented as a narrative literature review. Relevant primary sources published between 2016 and 2022 were identified and selected using data extraction and analysis methods. Results and discussion. The concept of “parasitic therapy” has generated considerable interest among researchers, the public, and patients for whom standard treatments have been ineffective or offered limited results. Although studies exploring the role of parasitic infections in arthritis are less common than in other fields, animal models suggest that parasitic infections may alleviate joint inflammation. However, further research is needed across different forms of arthritis, including clinical data collection and double-blind, controlled clinical trials. Conclusions. While only a few studies have demonstrated that parasitic infections may worsen preexisting diseases, the scientific consensus is that parasitic infections can create an immunoregulatory environment, reducing the severity of coexisting conditions. Finally, more rigorous animal studies are required to thoroughly investigate immunomodulatory mechanisms and potential side effects of parasitic infections in the presence of other diseases. Mon, 01 Jan 2024 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/30076 2024-01-01T00:00:00Z