http://repository.usmf.md:80/handle/20.500.12710/30955 Sun, 12 Apr 2026 13:58:31 GMT 2026-04-12T13:58:31Z http://repository.usmf.md:80/handle/20.500.12710/30967 Title: „Health status of employees in meat processing enterprises and preventive measures”. Authors: Iurie Pînzaru, Grigore Friptuleac, Agripina Rașcu Authors: Bahnarel, Ion Wed, 01 Jan 2025 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/30967 2025-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/30966 Title: Professor Victor Botnaru – 70 years of excellence in medicine and education Authors: Ceban, Emil Wed, 01 Jan 2025 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/30966 2025-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/30965 Title: COVID-19 as a possible risk factor for poor prognosis in systemic sclerosis Authors: Agachi, Svetlana; Popa, Serghei; Rotaru, Larisa; Russu, Eugeniu; Dutca, Lucia; Meleșco, Irina; Stog, Valeria Abstract: Introduction. Scleroderma Renal Crisis (SRC) is a life-threatening complication of systemic sclerosis (SSc), traditionally associated with anti-RNA polymerase III antibodies, corticosteroid use, and diffuse skin involvement. However, the role of COVID-19 as a potential trigger for SRC remains poorly understood. This study explores the occurrence of COVID-19-associated SRC, focusing on its clinical presentation, underlying risk factors, and outcomes. Case presentation. We present a case series of two unvaccinated patients with systemic sclerosis who developed SRC following COVID-19 infection, despite the absence of traditional risk factors. Clinical features, laboratory findings, renal histopathology, and disease progression were analyzed to assess potential mechanisms linking SARS-CoV-2 infection to SRC onset. Both patients developed abrupt-onset malignant hypertension and acute kidney injury after supporting the COVID-19. Neither patient had a history of corticosteroid use or known anti-RNA polymerase III positivity, suggesting an alternative mechanism of SRC activation. Notably, both cases had pre-existing renal anomalies (renal developmental abnormality and prior nephrectomy), which may have contributed to increased susceptibility. Despite aggressive management, both patients developed dialysis-dependent renal failure and succumbed to SRC-related complications. Conclusions. Our findings highlight COVID-19 as a potential trigger for SRC, possibly through endothelial dysfunction, inflammatory cytokine storms, and renal microangiopathy. The presence of pre-existing kidney conditions may further predispose SSc patients to SRC following SARS-CoV-2 infection. Additionally, the lack of vaccination in these cases raises the question of whether COVID-19 immunization could reduce SRC risk. Further research is needed to elucidate the pathophysiology, risk stratification, and long-term outcomes of COVID-19-associated SRC, as well as the role of vaccination in prevention. Wed, 01 Jan 2025 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/30965 2025-01-01T00:00:00Z http://repository.usmf.md:80/handle/20.500.12710/30964 Title: Chronic kidney disease – a major public health problem Authors: Groza, Costina; Groppa, Liliana; Rotaru, Larisa; Răzlog, Tatiana; Sasu, Dorian; Popa, Serghei Abstract: Introduction. Chronic kidney disease (CKD) is a major and growing global public health problem, contributing to significant morbidity, mortality, and financial strain on healthcare systems. Despite available preventive measures, CKD often remains underdiagnosed and insufficiently addressed by health policies worldwide. Materials and methods. A literature review was conducted using the MEDLINE electronic database via PubMed, Scopus, and the HINARI (Research4Life) program, focusing on studies published since 2001. Search terms included “primary care”, “chronic kidney disease”, “chronic kidney disease public health”, and “chronic kidney disease costs”. Original articles, meta-analyses, and systematic reviews were included, with English-language articles prioritized. Bibliographic references of selected publications were also examined to identify additional relevant studies. Results. CKD affects approximately 700-850 million people globally, with rising prevalence and mortality rates, especially in low- and middle-income countries. The disease disproportionately burdens vulnerable populations and health systems due to high direct and indirect costs, particularly for advanced-stage care. While cost-effective prevention and early detection strategies are available, their implementation is uneven, and policy responses have historically lagged. Successful national initiatives demonstrate that early intervention and integrated care can reduce the incidence and economic impact of end-stage kidney disease. Conclusions. CKD is a preventable, yet increasingly prevalent disease that requires urgent public health action. Prioritizing early detection, integrated care models, and policy reforms can significantly curb its global burden. Coordinated efforts at international, national, and local levels are essential to translate existing knowledge into effective practice and reduce the societal and financial costs of CKD. Wed, 01 Jan 2025 00:00:00 GMT http://repository.usmf.md:80/handle/20.500.12710/30964 2025-01-01T00:00:00Z