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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/10923
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dc.contributor.authorProcopciuc, Vitalie
dc.contributor.authorDumbraveanu, Lilia
dc.contributor.authorLupan, Valentina
dc.date.accessioned2020-07-05T20:33:11Z
dc.date.available2020-07-05T20:33:11Z
dc.date.issued2016
dc.identifier.citationPROCOPCIUC, Vitalie, DUMBRAVEANU, Lilia, LUPAN, Valentina. The use of amniotic membrane in the treatment of corneal ulcers and ocular surface defects. In: MedEspera: the 6th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2016, p. 187.en_US
dc.identifier.isbn978-9975-3028-3-8.
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/10923
dc.descriptionDepartment of Ophthalmology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016en_US
dc.description.abstractIntroduction: The human amniotic membrane (HAM) has been proved to possess a vast variety of beneficial effects (stimulation of epithelialization, antiangiogenic, antibacterial and antiinflamatory effects), which can be very useful in many ophthalmological indications, such as corneal trophic ulcers resistant to medication and some cases of ocular surface destruction.This paper is an attempt to introduce the HAM transplantation indications in ophtalmology, to present the methods an techniques of HAM aplication on the human eye, to describe our experience with the amniotic membrane and to analyse the transplantation outcomes in patients with corneal ulcers of diverse etiology. Materials and methods: A total of 19 patients were included in the study. All of them underwent HAM transplantation at the MCH „St. Trinity”. The patients presented corneal ulcers of various complexity and etiology and were distributed in 3 main categories: group A (n=14), which included patients with corneal erosions in dry eye syndrome (n=5), viral keratitis (n=6), persistent epithelial defects after corneal abscess (n=2) and chemical burns (n=1); group B (n=4), which included patients with severe stromal thinning and iminent corneal perforation; group C (n=1), with one case of symblepharon and extensive corneo-conjunctival adhesions. The HAM was prepared from a fresh placenta of a seronegative pregnant woman and stored at -80°C. The amniotic membrane was applied on the ocular surface using the „patch” technique. Results: The cornea regeneratedsatisfactory in 11 patientsout of 14 in group A, but the epithelial defect recurred in 3 of them. In the second group the transplantation was less effective - 2 patientsout of 4 needed further tectonic corneal graft and1 penetrant keratoplasty was performed. The HAM transplantation showed good results in symblepharon surgery, facilitating epithelialization and preventing corneo-conjunctival adhesions in the group C. Conclusions: The HAM transplantation showed good results in facilitating corneal healing and regeneration in patients with persistent epithelial defects, as well as preventing corneo-conjunctival adhesions followingsymblepharon surgery. Nevertheless, in some cases,further surgerywas needed for ocular surface reconstruction, as the HAM transplantation wasn’t effective enough to prevent the tectonic corneal graft if severe stromal thinning and impending corneal perforation were involved.en_US
dc.language.isoenen_US
dc.subjecthuman amniotic membrane
dc.subjectcorneal ulcers
dc.subject.ddc61:378.661(478-25)(082) M 54en_US
dc.titleThe use of amniotic membrane in the treatment of corneal ulcers and ocular surface defectsen_US
dc.typeArticleen_US
Appears in Collections:MedEspera 2016

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