USMF logo

Institutional Repository in Medical Sciences
of Nicolae Testemitanu State University of Medicine and Pharmacy
of the Republic of Moldova
(IRMS – Nicolae Testemitanu SUMPh)

Biblioteca Stiintifica Medicala
DSpace

University homepage  |  Library homepage

 
 
Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/10986
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMarusyk, U.I.
dc.contributor.authorMyslytska, G.O.
dc.date.accessioned2020-07-06T08:09:56Z
dc.date.available2020-07-06T08:09:56Z
dc.date.issued2016
dc.identifier.citationMARUSYK, U.I., MYSLYTSKA, G.O.. Features cellular link of immune response school-age children with late-onset asthma, depending on acetylation polymorphism. In: MedEspera: the 6th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2016, p. 59.en_US
dc.identifier.isbn978-9975-3028-3-8.
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/10986
dc.descriptionBukovina State Medical University, Chernivtsi, Ukraine, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016en_US
dc.description.abstractIntroduction. Bronchial asthma is one of the most common diseases in the world. It is believed that the inefficiency of controlling asthma therapy, which is observed in almost half of patients due, in particular, the presence of different asthma-phenotypes. Considering the literature data on the association of asthma with genetic polymorphisms Natsetyltransferase - an enzyme that determines feature metabolism, we thought it appropriate to assess the features of the state of cellular immunity in children with asthma late start, with their acetylation phenotypes. Our aim is to optimize late-onset asthma control, to evaluate some indicators of cellular parts of the immune system in children, considering acetylation phenotypes. Materials and Methods. Examined 72 children, late-onset asthma (disease first manifested itself in the age of 6 years). Over the course of the disease children were divided into two clinical groups. The first group included 34 patients who were evaluated slow type of acetylation (mean percentage of acetylated sulfadimezin in urine was less than 75.0%). The second clinical group formed 38 students, which was marked fast type of acetylation (mean percentage of acetylated sulfadimezin in urine was more than 75.0%). All children were tested for T-lymphocytes, T-helper cells and T killer/suppressor and B-lymphocytes blood.Discussion results. In 66.6% children "slow acetylation" observed reduction of CD-3 in peripheral blood of at least 34.0%, while in the second group these indicators occurred only in 42.1% of cases (Pφ> 0 05). This slow type of acetylation in children with late-onset asthma was Associate with the decline of CD-3 in peripheral blood (less than 34.0%) relative to the group "fast acetylation" as follows: relative risk - 1.7 (95% CI 1,3-2,2) the odds ratio of 2.7 (95% CI 1,5-4,8). Every second child (54,1%) for the slow type of acetylation phenotype of late-onset asthma reduced content recorded CD-8 (less than 18.0 g/l), while the comparison group - only 21,0% of patients (Pφ <0.05). The presence of slow acetylation phenotype in patients with late-onset asthma Associate with a decrease in the aforementioned content CD-22 cells in peripheral blood following: relative risk - 1.6 (95% CI 0,6-4, 1) at odds ratio - 3.6 (95% CI 1,3-10,1). Conclusion. Most patients with slow type of acetylation course of late-onset asthma Associated with a decrease in the CD-3, CD-4, CD-8 in peripheral blood and B-lymphocytes, which indirectly indicates the severity of chronic inflammatory allergic process in this persons.en_US
dc.language.isoenen_US
dc.publisherMedEsperaen_US
dc.subjectBronchial asthmaen_US
dc.subjectacetylation polymorphismen_US
dc.subjectpediatricsen_US
dc.titleFeatures cellular link of immune response school-age children with late-onset asthma, depending on acetylation polymorphismen_US
dc.typeArticleen_US
Appears in Collections:MedEspera 2016



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2013  Duraspace - Feedback