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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/10991
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dc.contributor.authorGavriliuc, Eugen
dc.date.accessioned2020-07-06T08:51:20Z
dc.date.available2020-07-06T08:51:20Z
dc.date.issued2016
dc.identifier.citationGAVRILIUC, Eugen. Clinical and paraclinical peculiarities of sensory CIDP and DADS polyneuropathies. In: MedEspera: the 6th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2016, p. 63-64.en_US
dc.identifier.isbn978-9975-3028-3-8.
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/10991
dc.descriptionDepartment of Neurology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016en_US
dc.description.abstractIntroduction.Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired disorder of peripheral nerves and nerve roots. The classic form of CIDP is fairly symmetric and motor involvement is greater than sensory. Recent series and epidemiologic data have shown that 35% of CIDP patients may have only sensory symptoms. The term distal acquired demyelinating symmetric (DADS) neuropathy was introduced by Katz et al. (2000) to describe a group of patients with predominantly distal sensory and ataxic demyelinating neuropathy. In our study we want to determine what are the most sensitive tests to perform in sensory CIDP and DADS, and what are the most frequent clinical findings in these patients. Materials and methods. We selected 14 patients with definite or probable sensory CIDP and 6 patients with DADS neuropathy according to the EFN/PNS guideline at the Center of Peripheral Disimunitary Polyneuropahy, Hospital Pitie-Sapletriere, Paris in the period 2010-2015. Clinical examination included the following scales: Overall Neuropathy Limitation Scale – (ONLS), 9 hole peg test, MRC (Medical Research Council). Nerve conduction studies (NCS) were performed in all the patients. A full routine biochemistry, immunofixation of proteins, all spectrum of anti-myeline and antiganglioside antibodies, cerebral spinal fluid (CSF) microscopic examination were performed.Results. There were 14 male and 6 female patients, ranging in age from 55 to 79 years. Evolution of disease is more sparing in sensory CIDP patients: 10 patients had stationary symptoms, while 5 DADS patiens had a proggresive course of the disease. All sensory CIDP patients had clinically pure sensory peripheral neuropathy and normal muscle strength according to MRC scale. In DADS group 3 patients had normal strength, and another 3 only distal weakness (MRC 95/100 points). Romberg sign was negative in 11 cases (78%) in sensory PDIC and positive in all DADS patients. Tremor was present in 50% cases of DADS, and only in 22% sensory PDIC patients. Average ONLS is 1,85± 0,286 in sensory CIDP and 3,6± 0,240 in DADS (p<0.001). In 90% cases with sensory CIDP or DADS deep tendon reflexes were diminished. Average level of proteins in CSF: 0,63g/l in sensory PDIC compared to 1,25 g/l in DADS (p<0.001). Average distal motor latencies (DML) in DADS patients: median nerv– 8,32±0,63 ms (p<0,001); ulnar nerv– 5,45±0,35 ms (p<0,05); peroneal nerv– 7,36±0,45 ms (p<0,05). Only 30% patients with sensory CIDP had demyelinating findings on NCS. Conclusions. DADS patients have a clinically sensory neuropathy with distal weakness, with ataxia as a predominant feature, frequent generalized areflexia and postural tremor. Gait ataxia is not common in sensory CIDP. NCS is not a sensitive test to diagnose sensory CIDP, in 70% cases motor conduction velocities were not affected. Uniform extensions of DML in all motor nerves on NCS is the key feature of DADS.en_US
dc.language.isoenen_US
dc.publisherMedEsperaen_US
dc.subjectsensory CIDPen_US
dc.subjectDADSen_US
dc.subjectpolyneuropathyen_US
dc.titleClinical and paraclinical peculiarities of sensory CIDP and DADS polyneuropathiesen_US
dc.typeArticleen_US
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