Breathe new life into chronic kidney disease

Abstract

Introduction. Chronic kidney disease (CKD) is a worldwide public problem. There is a rising incidence and prevalence of kidney failure with poor outcomes and high cost. The guidelines define CKD as kidney damage or decreased glomerular filtration rate (GFR) less than 60 mL/min/1.73m2 for at least 3 months. In Moldova, there were registered 490 patients with chronic kidney disease in 2017. Nowadays, dialysis and transplantation are 2 main solutions especially in end-stage kidney disease. Dialysis will prolong the life, but they will not have a normal life quality. Life expectancy of someone on dialysis is lower than that of the general population. Dialysis and transplantation are not fully available for all patients. Aim of the study. Analysis and comparing the data of latest studies performed in Europe and USA regarding new approach of CKD treatment, including exploring the field of artificial kidney grown in laboratories. Materials and methods. The principle of this study execution consists on exploring of different new and suitable methods of treatment and life quality improvement in patients with CKD. Meta-analysis of diverse studies is the key tool for disclosure of optimal strategies for kidney function improvement in the ends stage of diseases. Results. 1. Regenerative medicine holds the potential to fully heal damaged tissues and organs, offering solutions and hope for people who have conditions that today are beyond repair. 2. A new drug therapy that could potentially control protein leakage from the kidneys. 3. A new approach to prevent the kidney cell irreversible injury: AC1903. 4. Scientists have successfully produced human kidney tissue within a living organism, which is able to produce urine. Conclusions. The outcome of the study reveals a significant "win" on kidney disease. In Moldova patients reach late stages of chronic renal disease, because a lot them are addressing too late to medical care services. That’s why new treatment methods have a great importance to save lives of patients with CKD and to improve their life quality as well.