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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/11061
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dc.contributor.authorLupu, Roman-
dc.contributor.authorSpanu, Cristina-
dc.contributor.authorUncu, Andrei-
dc.contributor.authorDonici, Elena-
dc.date.accessioned2020-07-07T08:09:24Z-
dc.date.available2020-07-07T08:09:24Z-
dc.date.issued2018-
dc.identifier.citationLUPU, Roman, SPANU, Cristina, UNCU, Andrei, DONICI, Elena. Application of IR spectroscopy for evaluation of compatibility of drug substances with excipients. In: MedEspera: the 7th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2018, p. 277-278.en_US
dc.identifier.urihttps://medespera.asr.md/wp-content/uploads/Abastract-Book-2018.pdf-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/11061-
dc.descriptionDepartment of Pharmaceutical and Toxicological Chemistry, Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldovaen_US
dc.description.abstractIntroduction. The researchers conducted on interactions between different drug substances combined in the same dosage form are fundamental to avoid the instability of the finished medicinal product. IR spectroscopy is one of the oldest physical methods, being one of the most suitable for obtaining absorption spectra, which are then applied to determine the compatibility by using electromagnetic radiation to interact with the substances and to investigate, therefore, certain characteristics of the sample depending on the wavelength. Aim of the study. The bibliographic evaluation of IR techniques applied for the Exploring of compatibility of drug substances with excipients. Materials and methods. 68 abstracts and articles from systematic research in the Cochrane Electronic Library, MEDLINE databases. Results. Based on the absorption of infrared radiation by substances, IR spectroscopy provides sufficient information about the possible interactions between the active substances and excipients of a multicomponent dosage form. In all bibliographic sources, the Fourier Transformation Infrared Spectroscopy (FTIR) method is associated and complementary with other techniques for compatibility determination such as Differential Scanning Calorimetry (DSC), X-ray diffraction. The study of possible interactions between drug substances and excipients by using FTIR is performed by the KBr pellet method, where the IR spectra are first recorded individually, then in binary mixtures in the scanning range from 4000 to 500 cm-1. The obtained spectra are indicative for the nature of chemical bonds in the sample test and for the mixtures of substances, that can be used to identify the chemical structures or composition of the investigated sample. Overlapping peaks of substances and excipients in mixtures are analyzed and compared to peaks of individual spectra. Conclusions. It has been found that IR spectroscopy is a common, important and mandatory technique in assessing the compatibility of drug substances with excipients.en_US
dc.language.isoenen_US
dc.publisherMedEsperaen_US
dc.subjectIR spectroscopyen_US
dc.subjectcompatibilityen_US
dc.subjectdrug substancesen_US
dc.subjectexcipientsen_US
dc.titleApplication of IR spectroscopy for evaluation of compatibility of drug substances with excipientsen_US
dc.typeArticleen_US
Appears in Collections:MedEspera 2018

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