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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/11720
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dc.contributor.authorAndrieș, Elena
dc.date.accessioned2020-09-22T06:51:51Z
dc.date.available2020-09-22T06:51:51Z
dc.date.issued2020
dc.identifier.citationANDRIEȘ, Elena. Molecular, neurochemical and neurophysiological mechanisms of memory. In: MedEspera: the 8th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2020, p. 259-260.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/11720
dc.identifier.urihttps://medespera.asr.md/wp-content/uploads/ABSTRACT-BOOK.pdf
dc.descriptionDepartment of Human Physiology and Biophisics, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 8th International Medical Congress for Students and Young Doctors, September 24-26, 2020en_US
dc.description.abstractIntroduction. Learning and memory have proven to be fascinating mental processes because they address one of the fundamental features of human activity: our ability to acquire new informations and to retain it over time in memory. (Kandel ER, 2001). The brain has to process a continuous input from our sensory organs and at the same time it must be able to store memories, sometimes even for a lifetime. One of the fundamental questions in memory research is how our experiences of life can persist over time. What is the cellular foundation of this long-term information storage of neurons in neuronal networks, which is so important for humans? It is generally acknowledged that the memory processes are the result of the interplay between synaptic plasticity and orchestrated network activity that finally culminates in the long-term storage of information. Overall, information storage starts with the encoding of new information and progresses to the short-term memory. At this stage the engram might be either consolidated for a lifetime, destabilized, or restabilized in the course of memory retrieval. These neuronal dynamics start and end with synaptic and cellular plasticity and can be observed at the behavioral level (Korte M, Schmitz D, 2016). The formation of long-term memory involves gene transcription, protein synthesis and synaptic plasticity dynamics. This plasticity is dependent on a well-regulated program of neurotransmitter release, postsynaptic receptor activation, intracellular signaling cascades, gene transcription, and subsequent protein synthesis. In the last decade, epigenetic markers like DNA methylation and posttranslational modifications of histone tails have emerged as important regulators of the memory process. (Zovkic IB et al, 2013).en_US
dc.language.isoenen_US
dc.publisherMedEsperaen_US
dc.subjectsynaptic plasticityen_US
dc.subjectmemory consolidationen_US
dc.subjectinformation storageen_US
dc.subjectcell signalingen_US
dc.subjectlong-term potentiationen_US
dc.titleMolecular, neurochemical and neurophysiological mechanisms of memoryen_US
dc.typeArticleen_US
Appears in Collections:MedEspera 2020

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