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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/11731
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dc.contributor.authorTacu, Lilia
dc.date.accessioned2020-09-22T19:56:32Z
dc.date.available2020-09-22T19:56:32Z
dc.date.issued2020
dc.identifier.citationTACU, Lilia. The role of endothelin-1 in the doxorubicin cardiotoxicity. In: The Moldovan Medical Journal. 2020, vol. 63, no 4, pp. 43-48. ISSN 2537-6381. DOI: 10.5281/zenodo.4016812en_US
dc.identifier.issn2537-6381
dc.identifier.issn2537-6373
dc.identifier.urihttps://doi.org/10.5281/zenodo.4016812
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2020/09/MMJ-Vol-63-No-4-Oct-2020.pdf
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/11731
dc.descriptionDepartment of Pathophysiology and Clinical Pathophysiology Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldova, The 75th anniversary of Nicolae Testemiţanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020)en_US
dc.description.abstractBackground: The cardiotoxicity of doxorubicin (Dx), an antineoplastic drug, is imposed by the development of cardiomyopathy and heart failure. The expression of endothelin-1 (ET-1) in myocardium under the action of Dx, directly correlates with the degree of cardiac dysfunction, mediated by endothelin A (ETA) receptor. Material and methods: For prospective randomized study 2 groups of white rats (experimental group n=9, control group n=9) were used. During 2 weeks in the control group was administrated Dx (i/p, 4mg/kg in one dose, twice/week), cumulative dose – 16 mg/kg. The ET-1 effects were estimated at its peak action in concentration 10-7 M (mol), reproduced after 30 sec of endothelin stimulation. Results: The functional parameters of isolated heart perfused in physiologic regime and in condition of volume and resistance overload under the ET-1 action in the group with Dx compared with the control one, were reduced considerably, namely: cardiac output (CO); left ventricle systolic pressure (LVSP); left ventricle end-diastolic pressure (LVEDP). Conclusions: Under the ET-1 action on the isolated heart perfused in physiologic regime in the group with Dx – the LVSP and CO were reduced determining negative inotropic effect. At the volume overload test, under the ET-1 action, the diastolic impairment was more evident in the group with Dx, due to increased LVEDP. At the resistance overload test under the ET-1 action, the CO was reduced indicating the depreciation of myocardial contraction capacity.en_US
dc.language.isoenen_US
dc.publisherThe Scientific Medical Association of the Republic of Moldovaen_US
dc.relation.ispartofThe Moldovan Medical Journal: The 75th anniversary of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova (1945-2020)
dc.subjectdoxorubicin cardiomyopathyen_US
dc.subjectendothelin-1en_US
dc.subjectcoronary flowen_US
dc.subjectheart reactivityen_US
dc.subject.ddcUDC: 615.277.099:616.12en_US
dc.titleThe role of endothelin-1 in the doxorubicin cardiotoxicityen_US
dc.typeArticleen_US
Appears in Collections:The Moldovan Medical Journal, Vol. 63, No 4, October 2020

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