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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/12113
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dc.contributor.authorSavin, Natalia
dc.contributor.authorVislouh, Oxana
dc.contributor.authorUncu, Andrei
dc.date.accessioned2020-10-12T17:37:06Z
dc.date.available2020-10-12T17:37:06Z
dc.date.issued2016
dc.identifier.citationSAVIN, Natalia, VISLOUH, Oxana, UNCU, Andrei. Experimental determination of the logP using the spectrophotometric method. In: MedEspera: the 6th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2016, p. 328.en_US
dc.identifier.isbn978-9975-3028-3-8.
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/12113
dc.descriptionNicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016en_US
dc.description.abstractIntroduction: In order to estimate the bioavailability of drugs and their formulations together with the water solubility parameter, it is important to know the ability of a substance to pass through the cell membranes (lipid bilayer). For an approximate estimate of this capacity, it is used the term "lipophilicity", which represents the correlation between the dissolving of substance in water and noctanol, considered to be a solvent with a polarity close to the phospholipid structure of the cell membrane [1,2]. The purpose of this study was to determine experimentally the lipophilicity of a molecule of a new compound, derivative of oxathiodiazole with antimycobacterial properties, using the spectrophotometric method. Materials and methods: Spectrophotometer UV-VIS Agilent 8453, n-octanol, purified water, laboratory chemical dishes in accordance with requirements of Ph. Eur. Results and discussion: It was prepared the solution of the analyte in n-octanol with an estimated concentration so that the absorbance of the solution to be in the range 1,5-1,8. The solution was analyzed at the wavelength between 220-400 nm, fixing the analytical maximum at 300 nm. It was recorded the absorbance of octane solution: 0,99915. Subsequently, it was recorded the absorbance of the solution after adding an equal amount of water and stirring at the ultrasonic bath (1,01500). It was calculated the lipophilicity, which was expressed by the value logP, working at a pH of the aqueous phase in which the substance has the unionized state (1,799). Conclusion: The analyzed compound has an acceptable lipophilic level according to Lipinski's rules (less than 5), this value being confirmed by theoretical calculations and also by determinations of Thin-Layer Chromatography (TLC) method.en_US
dc.language.isoenen_US
dc.publisherMedEsperaen_US
dc.subjectlipophilicityen_US
dc.subjectspectrophotometryen_US
dc.subjectoxathiodiazoleen_US
dc.titleExperimental determination of the logP using the spectrophotometric methoden_US
dc.typeArticleen_US
Appears in Collections:MedEspera 2016

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