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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/12370
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dc.contributor.authorChelban, Dumitru-
dc.date.accessioned2020-10-29T07:14:44Z-
dc.date.available2020-10-29T07:14:44Z-
dc.date.issued2016-
dc.identifier.citationCHELBAN, Dumitru. The treatment of the diaphyseal bones defects using the method of induced membrane (preliminary study). In: MedEspera: the 6th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2016, p. 172-173.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/12370-
dc.descriptionDepartment of Orthopaedics and Traumatology, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, The 6th International Medical Congress for Students and Young Doctors, May 12-14, 2016en_US
dc.description.abstractIntroduction: The management of segmental long-bone defects is a challenge. The literature has described many techniques, but each is fraught with specific difficulties. Masquelet’s technique of induced membrane is now a reference surgical procedure for the treatment of complex lesions requiring bone regeneration. The concept of induced membrane was introduced by Alain-Charles Masquelet in 1986. The Masquelet method consists in formation of an induced membrane by a foreign body which has secretory properties, influencing positive on the regeneration and strengthening of the cancellous bone grafts. Aim: to investigate the morphological properties and characteristics of induced membrane which was modeled in an experimental group of rabbits in order to asses and to optimize the effectiveness of the Masquelet method in the clinic. Materials and methods: Experimental work was done using a group of rabbits (n=10) with the weight 5,5±0,5kg and the age 5 months. The investigation had 3 steps. The first step of the study consisted in creating the bone defect, filling it up with an antibiotic-impregnated cement spacer and stabilizing it with a plate. The second step of the study was 21 days later, consisting in incision of the induced membrane, removing the spacer and filling up the space with cancellous bone chips collected from iliac crest. At this stage we sacrificed 5 rabbits in order to perform the histological and morphological examination. At the sixth week we switched to the third step – ablation of metal construction and the radiological control exam. At this stage we sacrificed 5 rabbits to study the morphological aspect of the healed bone. Results: The histo-morphological examination performed at the 21 days demonstrated the presence of an inflamator process characterized by neutrophilic, eosinophilic elements and regeneration’s elements – fibroblasts. Also, it was determined a pseudo synovial metaplasia and a villous hyperplasia with formation of an synovial epithelium on the internal face of the induced membrane. The histo-morphological exam performed at the 6 weeks has demonstrated the continuation of the neoformating process and of the bone modelation, the regeneration process prevailed over the inflammatory one. The morphological aspect was formed by agglomerations of fibroblasts, myoblasts and collagen and numerous vascular buds, that promote a good neoangiogenesis and osteogenesis of the bone. Conclusion: The morphological study demonstrated an intense process of cell proliferation and differentiation, which highlights the biological role of induced membrane by foreign body with secretion of the osteoinductive factors, promoting the vascularization and corticalization of the bone. The Masquelet method is an effective method that allows getting the consolidation of the bone in case of critical size bone loss.en_US
dc.language.isoenen_US
dc.publisherMedEsperaen_US
dc.subjectbone defectsen_US
dc.subjectinduced membrane techniqueen_US
dc.subjectMasquelet techniqueen_US
dc.titleThe treatment of the diaphyseal bones defects using the method of induced membrane (preliminary study)en_US
dc.typeArticleen_US
Appears in Collections:MedEspera 2016

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