USMF logo

Institutional Repository in Medical Sciences
of Nicolae Testemitanu State University of Medicine and Pharmacy
of the Republic of Moldova
(IRMS – Nicolae Testemitanu SUMPh)

Biblioteca Stiintifica Medicala
DSpace

University homepage  |  Library homepage

 
 
Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/12734
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCatcov, Carolina
dc.date.accessioned2020-11-09T14:00:29Z
dc.date.available2020-11-09T14:00:29Z
dc.date.issued2020-10
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/12734
dc.identifier.urihttps://stiinta.usmf.md/ro/manifestari-stiintifice/zilele-universitatii
dc.descriptionDepartment of Pharmacology and Clinical Pharmacology, State University of Medicine and Pharmacy "Nicolae Testemiteanu" Chișinău, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltareen_US
dc.description.abstractIntroduction: Currently, advanced technology leading to ecological disasters, incorrect nutrition with many chemical additives, hard intellectual work, etc., affect the functionality of the immune system, predisposing the body to various attacks of microorganisms. All these directs researchers to study and discover new immunomodulatory drugs, including imupurin, a biologically active substance extracted from the larvae of butterflies of the order Lepidoptera, Lemantria family. Previous studies on the pharmacological properties of imupurin have shown that the preparation has an immunotropic effect; increases nonspecific resistance in vivo studies. Purpose: Study of the immunomodulatory effect of imupurin on leukocyte formula in dexamethasone-induced secondary immunodeficiency M aterial and methods: The study included 31 rats, weighing 180.80 ± 5.99, of both sexes. The animals were randomly divided into 3 groups: G0- were given intraperitoneal saline solution, 0,9%-0,2 ml, G1-was administered dexamethasone sol. 2.5 mg / kg / body; G2- was given imupurin, internally 500 mg / kg in combination with dexamethasone. For the prophylaxis of bacterial infections, 500 mg / l doxycycline was added to the water of the animals. To determine the immunomodulatory effect, was collected blood from the inferior cava vena after general anesthesia with ketamine. Results: Experimental research has shown that dexamethasone reduced the percentage of lymphocytes by 50% compared to the control-negative group (34.4 ± 6.73 versus 61.23 ± 3.35; P <0.05) and increased neutrophils (55, 78 ± 7.57 versus 28.36 ± 2.91; P <0.05). G2, wich received imupurine plus dexamethasone, resulted in a more significant reduction in During 5 weeks, animals were supervised; Go did not show any changes in behavior, the skin, mucous membranes and the hairy part remained unchanged. An insignificant change was weight gain of approximately 16.18 grams per batch. G1 showed weight loss of 38.4 grams per batch. A hair loss (alopecia) was observed on the entire body surface in all rats and towards the end of the study period the rats became apathetic, drowsy. In addition, diarrhea occurred in 2 rats, others 3- left ear infection, with the formation on the earlobe of some concretions(image nr.1, nr.2). The study group, were also monitored to determine body weight, which by the end of the study had decreased by up to 54 grams per group. The following table (Nr.2) shows the changes in body mass during the research. Conclusions: Dexamethasone produced a secondary immunodeficiency, and the preparation of entomological origin did not prevent glucocorticoid-induced lucocyte formula disorders.en_US
dc.language.isoenen_US
dc.publisherUniversitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu"en_US
dc.subjectimupurinen_US
dc.subjectdexamethasoneen_US
dc.subjectsecondary immunodeficiencyen_US
dc.subjectimmune systemen_US
dc.titleImmunomodulatory action of imupurin in dexametazone-induced secondary immunodefficiencyen_US
dc.typeOtheren_US
Appears in Collections:Culegere de postere



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2013  Duraspace - Feedback