| DC Field | Value | Language |
|---|
| dc.contributor.author | Dumitraș, Mariana | |
| dc.contributor.author | Ambros, Ala | |
| dc.date.accessioned | 2020-11-10T11:08:02Z | |
| dc.date.available | 2020-11-10T11:08:02Z | |
| dc.date.issued | 2020-10 | |
| dc.identifier.uri | https://stiinta.usmf.md/ro/manifestari-stiintifice/zilele-universitatii | |
| dc.identifier.uri | http://repository.usmf.md/handle/20.500.12710/12813 | |
| dc.description | “Nicolae Testemițanu” State University of Medicine and Pharmacy,
Chair of biochemistry and clinical biochemistry, Chisinau, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltare | en_US |
| dc.description.abstract | Introduction:
Micro-RNAs (miRNAs) were defined as small endogenous
non-coding RNAs consisting of 18-24 nucleotides,
responsible for the gene expression and involved in many
cellular processes (Figure 1). The expression of the
enzyme plasminogen activator inhibitor-1 (PAI-1), the
main modulator of thrombosis, fibrinolysis,
inflammation, angiogenesis and atherogenesis, encoded
by SERPINE-1 locus, has been recently discovered to be
inhibited or stimulated by different miRNAs [1]. The
exact role of miRNA as biomarkers and treatment targets
of fibrinolysis disorders remains the subject of
continuous research.
Purpose:
To study the literature data regarding the
role of miRNA in the processes of
fibrinolysis for identifying the possible
diagnostic and therapeutic strategies.
Material and methods:
There were analyzed: Wiley Online library,
Crossref, Google Scholar databases, using the
combination of the terms “miRNA in
fibrinolysis”, “regulation of plasminogen
activator inhibitor-1” in the articles published
between years 2012-2020.
Conclusions:
A number of miRNAs were suggested both as potential biomarkers
for the diagnosis of thrombotic disorders, and as a treatment
perspective for venous thrombosis. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova | |
| dc.subject | fibrinolysis | en_US |
| dc.subject | miRNA | en_US |
| dc.title | The role of micro-RNA in fibrinolysis | en_US |
| dc.type | Other | en_US |
| Appears in Collections: | Culegere de postere
|
