USMF logo

Institutional Repository in Medical Sciences
of Nicolae Testemitanu State University of Medicine and Pharmacy
of the Republic of Moldova
(IRMS – Nicolae Testemitanu SUMPh)

Biblioteca Stiintifica Medicala
DSpace

University homepage  |  Library homepage

 
 
Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/12822
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPavlovschi, Ecaterina-
dc.date.accessioned2020-11-10T12:27:38Z-
dc.date.available2020-11-10T12:27:38Z-
dc.date.issued2020-10-
dc.identifier.urihttps://stiinta.usmf.md/ro/manifestari-stiintifice/zilele-universitatii-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/12822-
dc.descriptionDepartment of Biochemistry and Clinical Biochemistry, “Nicolae Testemitanu” State University of Medicine and Pharmacy, Chisinau, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltareen_US
dc.description.abstractIntroduction: The pathobiochemical mechanism of hypertensive retinopathy (HR) is with certainty not established. High blood pressure by itself could not explain the retinal changes that occur, therefore additional pathogenetic mechanisms, such as oxidative stress/ antioxidant system imbalance, could be involved. Purpose: The study was designed to determine serum catalase (CAT) levels, a marker of oxidative stress/ antioxidant balance and to identify whether there is a correlation between catalase levels and degree of HR. Material and methods: 90 patients detected primarily with HR, divided according to the Keith-Wagener classification into: - GI - 40 with HR grade I - GII - 32 with HR grade II - GIII - 18 with HR grade III CAT activity was determined according to Koroliuk M. in the modification of Gudumac V. et al. (1996) and expressed as M ± DS. Analysis of variance (ANOVA) was used, taking age and sex as covariates, and p <0.05 being statistically significant. Results: There was a tendency for CAT activity to increase in the blood of patients with hypertension as HR progressed. The CAT level in GII increased compared to GI (+ 8%; 34.88 ± 8.91 μM / L vs. 32.37 ± 8.52 μM / L, p = 0.381), as well as in patients in GIII compared to GII (+ 11%; 38.67 ± 17.35 μM / L vs. 34.88 ± 8.91 μM / L, p = 0.152). The CAT level did not show a correlation with the HR degree (r = 0.057; p = 0.293). CAT is responsible for neutralizing peroxides generated under conditions of oxidative stress. The maintenance of activity at a normal level may attest the minor involvement of peroxides in retinal damage in hypertension. Conclusions: The increase in the severity of hypertensive retinopathy is not correlated with increased serum catalase activity. Therefore, further studies are needed to conclude the role of the oxidative stress / antioxidant system balance in the development of hypertensive retinopathy.en_US
dc.language.isoenen_US
dc.publisherUniversitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu"en_US
dc.subjectcatalaseen_US
dc.subjectoxidative stressen_US
dc.subjectantioxidant systemen_US
dc.subjecthypertensive retinopathyen_US
dc.titleDisorders of catalase activity in hypertensive retinopathyen_US
dc.typeOtheren_US
Appears in Collections:Culegere de postere

Files in This Item:
File Description SizeFormat 
33_Pavlovschi_DISORDERS_OF_CATALASE_ACTIVITY_IN_HYPERTENSIVE_RETINOPATHY_p.40.pdf327.58 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2013  Duraspace - Feedback