| DC Field | Value | Language |
|---|
| dc.contributor.author | Tighineanu, Nicoleta-Ionica | |
| dc.date.accessioned | 2020-11-11T10:48:23Z | |
| dc.date.available | 2020-11-11T10:48:23Z | |
| dc.date.issued | 2020-10 | |
| dc.identifier.uri | https://stiinta.usmf.md/ro/manifestari-stiintifice/zilele-universitatii | |
| dc.identifier.uri | http://repository.usmf.md/handle/20.500.12710/12858 | |
| dc.description | State University of Medicine and Pharmacy „Nicolae Testemiţanu”, Catedra de
biochimie și biochimie clinică, Chisinau, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltare | en_US |
| dc.description.abstract | Introduction:
Vit.D receptor (VDR) and the
enzymes that metabolize this
vitamin have an impact, not only
on the homeostasis of calcium
and phosphate, but also on other
tissues.
This allows the possibility to
discover new aspects of
metabolism and clinical
implications of vitamin.
Purpose:
To analyze and synthesize modern
data from the literature on the
pleiotropic effects of vitamin D, the
importance, causes, mechanism and
consequences of its metabolism
defects to identify new diagnostic
and therapeutic strategies.
Material and methods:
Recent data on international scientific literature were analyzed, especially in
the PubMed and PubMed Central online library.
Results:
Vitamin D participates in a lot of processes
due to VDR and RXR receptors that are
found in different tissues.
The enzymes and genes that encode them
like CYP2R1, CYP27B1, CYP24A1, etc, play an
important role in the development of these
processes.
The disturbance of the metabolism enzymes
enhances the correlation between Vit.D and
a number of diseases such as: prostate,
breast, colorectal cancer, diabetes etc.
Conclusions:
The enzymes and genes involved in
the metabolism of the vitamin and its
action have effects on different cells.
Treatment and supplementations with
Vit.D, with variable dose, starting 400
U/l attenuates the manifestations of
symptoms as well as the risk of
developing other diseases. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova | en_US |
| dc.subject | vitamin D | en_US |
| dc.subject | metabolism | en_US |
| dc.subject | mechanism of action | en_US |
| dc.subject | effects | en_US |
| dc.title | Vitamin D (Vit.D) and diseases associated with its metabolism | en_US |
| dc.type | Other | en_US |
| Appears in Collections: | Culegere de postere
|
