DC Field | Value | Language |
dc.contributor.author | Dragan, Diana | - |
dc.contributor.author | Doțen, Natalia | - |
dc.date.accessioned | 2020-11-22T16:42:59Z | - |
dc.date.available | 2020-11-22T16:42:59Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.uri | https://stiinta.usmf.md/ro/manifestari-stiintifice/zilele-universitatii | - |
dc.identifier.uri | http://repository.usmf.md/handle/20.500.12710/13157 | - |
dc.description | State University of Medicine and Pharmacy Nicolae Testemitanu, National Center for Epilepsy, Chisinau, Republic of Moldova, Congresul consacrat aniversării a 75-a de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemițanu” din Republica Moldova, Ziua internațională a științei pentru pace și dezvoltare | en_US |
dc.description.abstract | Introduction
Transient epileptic amnesia (TEA) is a rare clinical
manifestation of temporal lobe epilepsy that occurs in
middle-age individuals, usually between 50 and 60 years of
age, with male predominance. TEA can be easily
interpreted as episodes of global transient amnesia, which
are often the reason for delaying appropriate treatment.
Purpose of this study is to evaluate the clinical features and neuropsychological
profile of patients with TEA.
Material and methods
Patients were clinically evaluated in the National Center for
Epilepsy, Chișinău, Republic of Moldova and diagnosed with
TEA based on diagnostic criteria proposed by Zeman and
Butler, 1998. Also, were monitored with EEG for 120 and
180min. Cerebral imaging was performed on high resolution
MRI. Neuropsychological assessed with MoCA test, Luria
verbal memory test and complex figure REY.
Case 1
Patient B.A., a 42-year-old man, was address for
recurrent episodes of short-term memory
impairment (transient amnesia), that started at the
age 37. The episodes were mostly on awakening,
when he does not remember the name of his
children, spouse or "forgets" to perform some
actions (for ex. forget how to drive a car), with a
duration for 5-10 min weekly. One year ago, he
experienced two tonic-clonic seizures on awakening
in the same day.
EEG telemetry 180min (Fig.1). MRI epilepsy
protocol without structural changes in the
hippocampus. On neuropsychological evaluation he
demonstrated impairment of immediate verbal
memory (Fig.2), autobiographical memory with
confusion in personal data and procedural memory.
Carbamazepine was started, being free of episodes of
memory disturbance or epileptic seizures for 12
months.
Case 2
Patient M.E., a 52-year-old woman, addressed for
frequent episodes of memory gaps for almost 4 years.
She could not remember some important events in
her life(she forgot how was celebrated the 20 birth
day of he daughter), without motor elements of
seizure.
On neuropsychological evaluation is an important
autobiographical memory impaired that was
associated with verbal memory impairment and
moderately low verbal fluency and
immediate/episodic memory impairment (Fig.3).
Video EEG telemetry 120min identified interictal
epileptiform discharges left temporal lobe. MRI
without structural changes (Fig.4).
Carbamazepine was initiated, being free of episodes
of memory disturbance for 28 months.
Results
the reported cases have an early onset, than previously
reported (Table 1), which makes diagnosis even more
difficult.
➢ the seizures were short associated or not (case 2) with
ictal motor elements.
➢ patients manifested persistent disturbance of
short-term and autobiographical memory interictaly,
identified by neuropsychological evaluation.
➢ IEDs were found in sleep in the temporal areas.
➢ Patients responded well to antiepileptic treatment and
have a good outcome.
➢ Our findings were confident with others case report
studies (Table 1).
Conclusions
TEA is a benign and treatable distinctive syndrome. It is
important for the attending neurologists to identify this
patients and should not be confused with other transient
amnesias. Video EEG telemetry and neuropsychological
evaluation by a trained specialist are the clues for diagnosis
of this syndrome for a better life of this patients. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" | en_US |
dc.subject | transient epileptic amnesia | en_US |
dc.subject | autobiographical memory | en_US |
dc.subject | temporal lobe epilepsy | en_US |
dc.title | Clinical and neuropsychological profile of patients with transient epileptic amnesia. Clinical case report | en_US |
dc.type | Other | en_US |
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