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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/13492
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dc.contributor.authorКурбат, М. Н.-
dc.contributor.authorЦыркунов, В. М.-
dc.contributor.authorКравчук, Р. И.-
dc.date.accessioned2020-11-30T18:44:21Z-
dc.date.available2020-11-30T18:44:21Z-
dc.date.issued2015-10-
dc.identifier.isbn978-9975-57-194-4-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/13492-
dc.descriptionЦентральная научно-исследовательская лаборатория, Гродненский государственный медицинский университет, Гродно, Беларусь, Conferința Ştiinţifică Internaţională ”Probleme actuale ale morfologiei” dedicată celor 70 de ani de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemiţanu”, Chişinău, 15-16 octombrie 2015en_US
dc.description.abstractAbstract Background: Recently, mitochondrial dysfunction mechanisms play a central role in the development of side effects of antiretroviral drugs, which play a key role in the treatment of HIV infection. Material and methods: Morphometric parameters of hepatocyte mitochondria were studied in primary and repeated liver biopsy of HIV-infected patient with side effect lipodystrophy, while taking nucleoside reverse transcriptase inhibitors. Results: Under condition of antiretroviral toxic affect on liver mitochondria an increase in optical density matrix of the mitochondria, which indicates their condensation. According to the literature, these changes are accompanied by functional abnormalities of mitochondria and preceded by induction mediated mitochondrial mechanisms of programmed death of cells which occurs in the final stage of the mitochondrial apoptosis pathway. Intermembrane space expands, due to which the total amount of mitochondria remains the same. The most important functionally structure of mitochondria - the inner membrane - at this stage, maintained, despite the fact that the observed expansion of christie. Condensation and swelling of mitochondria may reflect functional cell voltage, but growing increasingly toxic effects. Conclusions: Thus, against toxic effects of antiretroviral drugs hepatocytes in liver tissue formed complex structural changes of mitochondria, more objective evidence of the development of degenerative diseases in these organelles in drug therapy for HIV infection.en_US
dc.language.isoruen_US
dc.publisherProbleme actuale ale morfologiei: Materialele Conferinţei ştiinţifice internaţionaleen_US
dc.subjectliveren_US
dc.subjectmitochondriaen_US
dc.subjectelectron microscopyen_US
dc.subjectside effecten_US
dc.subjectHIVen_US
dc.titleМорфометрия митоходрий печени при токсическом воздействии антиретровирусной терапииen_US
dc.title.alternativeMorphometry of mitochondria of the liver under toxic effects of antiretroviral therapyen_US
dc.typeArticleen_US
Appears in Collections:PROBLEME ACTUALE ALE MORFOLOGIEI 2015

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