Половые особенности морфологических изменений паренхимы лёгких крыс при введении итраконазола и коррекции ксеногенной цереброспинальной жидкостью

Abstract

Abstract Background: There are the data indicating the positive influence of itraconazole (I) at fungal infections, non-small cell pulmonary carcinoma and prostatic cancer. The information about changes in the pulmonary parenchyma under introduction of I is still scanty. Previously we have noted that parenteral introduction of xenogenic cerebrospinal fluid (XCSF) results in decrease of intensity of collagen fibers and positive influence over characteristics of lung’s morphometry. Material and methods: The research was performed on 30 Wistar rats, which were divided into the following groups: the placebo group, the group which was getting I and placebo, the group which was getting I and XCSF. The animals were divided into subgroups by sex. The parenchyma was studied by morphological methods. Results: The introduction of I to Wistar rats resulted in increase of percentage of emphysematous areas at the expense of decrease of percentage of the areas with intact parenchyma; this effect was more pronounced at female rats. The introduction of XCSF to the female rats, which were getting I, resulted in increase of percentage of the intact areas at the expense of reduced percentage of emphysematous areas. The introduction of XCSF to male rats, which were getting I, resulted in increase of emphysematous areas at the expense of reduce of the percentage of non-changed parenchyma; this was also accompanied by more pronounced collagen formation. Conclusions: Introduction XCSF female rats has a protective effect, and males - worsened histologic.