| DC Field | Value | Language |
|---|
| dc.contributor.author | Bugai, Rodica | |
| dc.contributor.author | Barbacar, Nicolae | |
| dc.contributor.author | Ţîbîrnă, Ion | |
| dc.date.accessioned | 2019-06-13T11:14:43Z | |
| dc.date.available | 2019-06-13T11:14:43Z | |
| dc.date.issued | 2016 | |
| dc.identifier.citation | BUGAI, Rodica, BARBACAR, Nicolae, ŢÎBÎRNĂ, Ion. Mutaţia genică R117H (CFTR) la pacienţii cu pancreatită cronică din Republica Moldova. In: Sănătate Publică, Economie şi Management în Medicină. 2016, nr. 2(66), pp. 95-98. ISSN 1729-8687. | en_US |
| dc.identifier.issn | 1729-8687 | |
| dc.identifier.uri | http://repository.usmf.md/handle/20.500.12710/1515 | |
| dc.identifier.uri | http://revistaspemm.md/wp-content/uploads/2019/05/cm2_66_2016cg.pdf | |
| dc.description | USMF Nicolae Testemițanu, Laboratorul de Genetică Moleculară al
Institutului de Genetică al AȘM, Conferinţa consacrată aniversării celor 40 de ani de la fondarea SCM Sfânta Treime 17 iunie 2016 Chișinău, Republica Moldova | en_US |
| dc.description.abstract | Genetic studies in recent decades have proven the importance of CFTR gene mutations in the pathophysiology of chronic pancreatitis (CP). The aim of the study was to determine the frequency of R117H (CFTR) mutation in CP patients in Moldova vs healthy people. The results revealed a higher, statistically signicant, frequency of the mutation R117H (CFTR) in CP patients vs healthy people, in homozygous variant, predominantly in the patients with latent CP and a frequent combination with the other mutations (N34S/SPINK1 and R122H/ PRSS1), which reflects the high degree of risk posed by these mutations in the heterogeneous population of Moldova. | en_US |
| dc.description.abstract | Генетические исследования последних десятилетий доказали важность мутаций гена CFTR в патофизиологии хронического панкреатита (ХП). Цель исследования состояла в том, чтобы определить частоту мутаций R117H (CFTR) у больных с ХП в Молдове и у здоровых людей. Результаты выявили более высокую, статистически значимую, частоту мутации R117H (CFTR) у больных с ХП по сравнению со здоровыми, преимущественно в гомозиготнoм варианте у пациентов с латентным ХП и частые комбинации с другими мутациями (N34S/SPINK1 и R122H/PRSS1), что отражает высокую степень риска, связанного с этими мутациями, в гетерогенной популяции Республики Молдовы. | |
| dc.language.iso | ro | en_US |
| dc.publisher | Asociația Obștească ”Economie, Management și Psihologie în Medicină” din Republica Moldova | en_US |
| dc.subject | chronic pancreatitis | en_US |
| dc.subject | R117H /CFTR | en_US |
| dc.subject.mesh | Pancreatitis, Chronic--genetics | en_US |
| dc.subject.mesh | Mutation | en_US |
| dc.subject.mesh | Moldova | en_US |
| dc.title | Mutaţia genică R117H (CFTR) la pacienţii cu pancreatită cronică din Republica Moldova | en_US |
| dc.title.alternative | R117H (CFTR) gene mutation in the patients with chronic pancreatitis from the Republic of Moldova | en_US |
| dc.title.alternative | Mутация гена R117H (CFTR) у больных с хроническим панкреатитом в Республике Молдова | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | Sănătate Publică, Economie şi Management în Medicină Nr. 2 (66) / 2016
|
