| DC Field | Value | Language |
|---|
| dc.contributor.author | Харчу, И. Д. | |
| dc.contributor.author | Касьян, И. Г. | |
| dc.contributor.author | Касьян, А. К. | |
| dc.contributor.author | Симонова, Л. Л. | |
| dc.date.accessioned | 2021-04-04T12:11:04Z | |
| dc.date.available | 2021-04-04T12:11:04Z | |
| dc.date.issued | 2014 | |
| dc.identifier.citation | ХАРЧУ, И. Д., КАСЬЯН, И. Г., КАСЬЯН, А. К., СИМОНОВА, Л. Л. Оптимизация подготовки проб для химико-токсикологического анализа барбитуратов методом ВЭЖХ. In: Revista Farmaceutică a Moldovei. 2014, nr. 1-2, pp. 28-32. ISSN 1812-5077. | en_US |
| dc.identifier.issn | 1812-5077 | |
| dc.identifier.uri | http://repository.usmf.md/handle/20.500.12710/16523 | |
| dc.description | Кафедра фармацевтической и токсикологической химии, ОУ ГУМФ им. Николае Тестемицану, Научный Центр по Исследованию Лекарств, ОУ ГУМФ им. Николае Тестемицану | en_US |
| dc.description.abstract | Rezumat.
Optimizarea preparării probelor pentru analiza chimico-toxicologică a barbituricilor prin metoda HPLC.
În lucrarea dată au fost studiate unele procedee simple de preparare a probelor de material biologic pentru dozarea ulterioară a barbituricilor prin metoda HPLC. Ca procedeu optim se propune deproteinizarea cu amestec metanol – 2 M H2
SO4 (95:5). Acest procedeu în ansamblu cu analiza HPLC-UV asigură regăsirea barbituricilor cel puţin 97% din plasma sanguină şi o linearitate înaltă a dependenţei de calibrare în întregul diapazon studiat al concentraţiilor (până la 160 mg/l) cu limita de cuantificare circa 1 mg/l. | en_US |
| dc.description.abstract | Abstract.
In the present work have been studied some simple procedures of biological material sample preparation for the following assay of barbiturates by the HPLC method. As an optimum way it is offered deproteinization by the mixture of methanol and 2 M H2 SO4 (95:5). This procedure in combination with HPLC-UV analysis ensures recovery of barbiturates not less than 97% from blood plasma and high linearity of the calibration dependence in whole investigated range of concentrations (up to 160 mg/l) at limit of quantification about 1 mg/l. | en_US |
| dc.language.iso | ru | en_US |
| dc.publisher | Asociația Farmaciștilor din Republica Moldova | en_US |
| dc.relation.ispartof | Revista Farmaceutică a Moldovei | en_US |
| dc.subject | Barbiturates | en_US |
| dc.subject | chemical-toxicological analysis | en_US |
| dc.subject | sample preparation | en_US |
| dc.subject | HPLC | en_US |
| dc.title | Оптимизация подготовки проб для химико-токсикологического анализа барбитуратов методом ВЭЖХ | en_US |
| dc.title.alternative | Optimization of the sample preparation for the chemical-toxicological analysis of barbiturates by the HPLC method | en_US |
| dc.type | Article | en_US |
| Appears in Collections: | Revista Farmaceutică a Moldovei Nr. 1-2, 2014
|
