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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/16634
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dc.contributor.authorBologan, Lorena Nicoleta-
dc.date.accessioned2021-04-11T08:51:08Z-
dc.date.available2021-04-11T08:51:08Z-
dc.date.issued2017-
dc.identifier.citationBOLOGAN, Lorena Nicoleta. Sinteza şi caracterizarea spectrală a unor noi aminali cu potenţială activitate antibacteriană şi antifungică = Synthesis and spectral characterization of new aminals with antibacterial and antifungal potential activity. In: Revista Farmaceutică a Moldovei. 2017, nr. 1-2, p. 25. ISSN 1812-5077.en_US
dc.identifier.issn1812-5077-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/16634-
dc.descriptionUniversitatea de Medicină şi Farmacie „Carol Davila”, Bucureşti, ROMÂNIAen_US
dc.description.abstractIntroducere. Sunt raportate în literatură utilizări ale pirazolilor şi ftalimidei în sinteza unor compuşi cu acţiune analgezică, antioxidantă, antifungică sau bacteriostatică. Scopul lucrării. Lucrarea prezintă sinteza şi caracterizarea spectrală a unor noi aminali heterociclici nesimetrici folosind N-clormetilftalimidă şi pirazoli. Material şi metode. Ftalimida a fost sintetizată pornind de la anhidrida ftalică prin tratare cu amoniac la reflux, 3 ore. A urmat transformarea în sare de potasiu folosind KOH în etanol absolut, la reflux şi alchilarea cu CH2CI2 în DMF. NClorometilftalimida a fost folosită pentru a alchila la azot diferiţi pirazoli. Rezultate. La sinteza ftalimidei mediată prin microunde s-a constatat reducerea timpului de lucru (8 min.) şi un randament superior. Sinteza N-clorometilftalimidei, s-a realizat prin încălzire clasică. Alchilarea unor pirazoli cu Nclorometilftalimidă, s-a realizat atât prin reflux în solvenţi polari cât şi prin încălzire cu microunde. în cazul sintezei mediate de microunde randamentele simt mai mari şi timpii de lucru semnificativ scăzuţi. Concluzii. încălzirea cu microunde folosind solvenţi polari cu p f scăzute (ex. DMF) este o metodă eficientă, încălzirea clasică în solvenţi foarte polari (DMSO, HMPA) este costisitoare, îndepărtarea solventului se face mai greu şi cu pierderi de produs. Spectrele de UV, IR, RMN şi MS confirmă structurile moleculare deduse pe baza ecuaţiilor reacţiilor chimice.en_US
dc.description.abstractIntroduction. It has been reported that pyrazoles and phthalimide have found use in the synthesis of compounds with analgesic, antioxidant, antifungal or bacteriostatic activity. The aim of the study. This paper presents the synthesis and spectral characterization of new non-symmetrical heterocyclic aminals using N-chloromethylphthalimide and pyrazoles. Material and methods. Phthalimide was synthesized by treatment of phthalic anhydride with ammonia at reflux during 3 h. This was followed by conversion to the potassium salt using KOH in absolute ethanol at reflux and alkylation with CH2CI2 in DMF. N-Chloromethylphthalimide was used to alkylate different pyrazoles at the nitrogen site. Results. It has been found that during microwave mediated synthesis of the phthalimide the work time is reduced (8 min) and a higher yield is observed. Synthesis of N-Chloromethylphthalimide, was achieved by conventional heating. Alkylation of pyrazoles with NChloromethylphthalimide, was carried out as by reflux in polar solvents, as by microwave heating. In case of microwave mediated synthesis yields are higher and working time is significantly reduced. Conclusions. Microwave heating using polar solvent with low p f (eg. DMF) is an effective method. Classical heating in highly polar solvents (DMSO, HMPA) is expensive, the solvent removal is difficult and with product loss. The UV, IR, NMR and MS spectra confirmed the molecular structures deduced from the equations of chemical reactions.en_US
dc.publisherAsociația Farmaciștilor din Republica Moldovaen_US
dc.relation.ispartofRevista Farmaceutică a Moldovei: The First Congress of Pharmaceutical Students Association from Republic of Moldova dedicated to the Year Nicolae Testemitanu "Innovation and creativity in pharmaceutical practice and research”, May 4-7, 2017, Chisinau, Republic of Moldovaen_US
dc.subjectunsimetric heterocyclic aminalsen_US
dc.titleSinteza şi caracterizarea spectrală a unor noi aminali cu potenţială activitate antibacteriană şi antifungicăen_US
dc.title.alternativeSynthesis and spectral characterization of new aminals with antibacterial and antifungal potential activityen_US
dc.typeArticleen_US
Appears in Collections:Revista Farmaceutică a Moldovei Nr. 1-2, 2017

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