Nivelul interleukinelor la copii în afecţiunile bronhoobstructive acute de etiologie micoplasmică

Abstract

Aim of our study was to evaluate changes of the interleukin 2 (IL-2) and interleukin 4 (IL-4) in the peripheral blood of children with Mycoplasma pneumoniae bronhoobstructive diseases. Material and Methods. The study included 33 children, aged 6 months - 7 years, with pneumonia and wheezing. Changes of IL-2 and IL-4 in peripheral blood in acute Mycoplasma pneumoniae infection were evaluated. Levels of Mycoplasma pneumoniae-specific antibodies (IgM, IgG), the peripheral blood concentrations of IL-2 and IL-4 were determined in serum samples obtained at enrollment from all 33 children that were tested by ELISA. Results. There were two study visits: first at admission and the second one – after 1 month. Twenty patients completed the study group with Mycoplasma-positive infection and 13 children completed the control group - Mycoplasmanegative infection. IL-2 levels in children with Mycoplasma-positive bronchopulmonary disease was 31,80±2,26 pg/ ml and in Mycoplasma-negative group 39,27±3,17 pg/ml, IL-4 levels was 46,92±2,93 pg/ml versus 52,36±2,17pg/ml, respectively. After 1 month in Mycoplasma-positive group IL-2 levels had increased (39,68±6,84pg/ml). No significant changes were observed for IL-4 values in the period of one month after the admission (47,75±2,19 pg/ml). Conclusion. There was observed an imbalance of the immune response with significant decrease of IL-2 levels and to a lesser extent of IL-4 in children with M. pneumoniae infection at the acute phase in our study, suggesting necessity of administration of therapeutic program for control of infectious inflammatory process in Mycoplasmal bronhoobstructive diseases.

В исследование были включены 33 ребёнка, в возрасте 6 месяцев-7 лет, с диагнозом пневмония и обструктивный бронхит, для изучения влияния микоплазменной инфекции на уровень ИЛ-2, ИЛ-4. Было предусмотрено обследование пациентов при поступлении и повторное обследование через 1 месяц. Уровень ИЛ-2 в сыворотке крови детей с микоплазменной инфекцией составлял в среднем 31,80±2,26пг/мл, а в группе контроля – 39,27±3,17пг/мл. Значение содержания в крови ИЛ-4 в исследуемой группе было 46,92±2,93пг/мл и в группе контроля – 52,36±2,17пг/мл.