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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/17874
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dc.contributor.authorVrynchanu, Nina
dc.contributor.authorKorotkij, Yurii
dc.contributor.authorHrynchuk, Nataliia
dc.contributor.authorBoiko, Irina
dc.contributor.authorSmertenko, Elena
dc.contributor.authorBondarenko, Larisa
dc.date.accessioned2021-06-17T12:34:49Z
dc.date.available2021-06-17T12:34:49Z
dc.date.issued2021
dc.identifier.issn2587-3466
dc.identifier.issn2587-3458
dc.identifier.urihttps://doi.org/10/38045/ohrm.2021.3.04
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/17874
dc.identifier.urihttps://journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/115/94
dc.descriptionSI Institute of Pharmacology and Toxicology of NAMS of Ukraine, Kyiv, Ukraine, Institute of organic chemistry of NAS of Ukraine, Kyiv, Ukraineen_US
dc.description.abstractIntroduction. The microbial biofilm-forming ability is one of the major aspects of the emerging issue of antibiotic resistance, which makes them tolerant to antibiotics and host defense systems and other external stresses, thus contributing to persistent chronic infections. A series of relevant studies confirmed the high efficiency of aminopropanol derivatives as potential antibacterial and antifungal agents. This present study was aimed to evaluate the antimicrobial activity of new 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivatives on the planktonic bacterial/fungal cells and biofilms. Material and methods. The minimum inhibitory concentrations (MIC) of the new compounds were determined by a standard method, along with their effects on biofilms estimated via the gentian violet adsorption-desorption assay. Results. The КVM-219 compound showed the most pronounced effect on planktonic bacterial and fungal cells. The MIC values ranged between 0.78 μg/mL to 12.5 μg/mL, depending on the microbial strain. The KVM-316 compound exhibited the strongest inhibitory effect on biofilms, thus preventing their formation by S. aureus (96.1%), E. coli (57.2%), and P. aeruginosa (96.1%). Conclusions. The 15 newly synthesized 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2- propanol] derivatives revealed marked antibacterial and antifungal effects on planktonic microorganisms. Most of these compounds showed a strain-specific inhibition of biofilm formation by at least 50% for S. aureus 222, E. coli 311, P. aeruginosa 449 and C. glabrata 404 strains.en_US
dc.description.abstract1-[(2,4(di-terț-butylphenoxy))-3-dialkylamino-2-propanol] asupra celulelor planctonice bacteriene/fungice și asupra biofilmelor. Material și metode. Concentrațiile minime inhibitorii (CMI) ale compușilor noi au fost determinate printr-o metodă standard, activitatea antibiofilm a fost testată prin absorbția violetului de gențiană pe structuri formate pe plăci de polistiren, urmată de resolubilizare cu solvent organic și resazurină ca indicator redox. Rezultate. Efectul cel mai pronunțat asupra celulelor planctonice bacteriene și fungice l-a demonstrat compusul КVM - 219, CMI 0,67 μg/ml - 12,5 μg/ml, în funcție de microorganism, iar asupra biofilmelor - compusul KVM-316. KVM-316 a prevenit formarea biofilmelor de către S. aureus (96,1%), E. coli (57,2%) și P. aeruginosa (96,1%). Concluzii. Cei 15 derivați nou sintetizați ai 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] au prezentat efecte antibacteriene și antifungice pronunțate asupra microorganismelor planctonice. Majoritatea acestor compuși au inhibat în mod specific formarea biofilmelor de către tulpinile clinice S. aureus 222, E. coli 311, P. aeruginosa 449 și C. glabrata 404 cu cel puțin 50%.en_US
dc.language.isoenen_US
dc.publisherAsociația de Biosiguranță și Biosecuritate din Republica Moldovaen_US
dc.relation.ispartofOne Health & Risk Managementen_US
dc.subjectaminopropanol derivativesen_US
dc.subjectantimicrobial activityen_US
dc.subjectbacteriaen_US
dc.subjectbiofilmen_US
dc.subject.ddcCZU: 579.61:547.435+615.281en_US
dc.titleAntimicrobial activity of novel 1-[(2,4-(di-tert-butylphenoxy))-3-dialkylamino-2-propanol] derivativesen_US
dc.title.alternativeActivitatea antimicrobiană a noilor derivați de 1-[(2,4-(di-tertbutylphenoxy))-3-dialkilamino-2-propanol]en_US
dc.typeArticleen_US
Appears in Collections:One Health & Risk Management Vol. 2 No 3, 2021

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