Using rabbits as experimental animals for modeling appendectomy during practice-oriented trainings as an alternative to engaging in an experiment dogs

Abstract

Introduction: Among the diseases of the abdominal cavity, requiring immediate surgery, the most frequent acute appendicitis. In connection with the execution of the rules of the obligation of experimental work in experimental animals, weare unable to demonstrate the technique of appendectomy on dogs because considere appropriate to use rabbits as an alternative to engaging in an experiment dogs. Purpose and Objectives: To compare the topographic-anatomic location and structure of the appendix of rabbit with a human, as well as to simulate and compare the stages o f appendectomy. Materials and Methods: After studying and analyzing the literature data concerning the location and topographic anatomical structure of abdominal viscera clinically healthy rabbit, and the study of this is sue in the anatomical dissection of the rabbit, we have carried out a number of appendectomies in experimental animals as follows: after general anesthesia by intramuscular injection of 10% solution of sodium thiopental (0.5 ml per 1 kg of body weight), was carried out fixing the animal and sitepreparation section. The abdomen was opened through a midline incision average. Peritoneum is olated gauze. Conducted an audit of the abdominal cavity. Finding the cecum with vermiform appendix removed the min to the wound. Further mobilization process was carried out, direct ligation of the segmental branches outside the walls of the appendix, and the vessels going to the adjacent intestinal loop, and bandaging the appendicular artery. After mobilization, the base of the appendix silk ligature was applied , above which the process of crossing. Stump was treated with 5 % solution of iodine. Inspection has been performed and hemostasis layers sutured abdominal wall. Results: Comparison of topographic and anatomical features of the location and structure of the appendix with a human rabbit showed that these anatomical structures are veryclose. Accordingly, the technique of surgery carried out was close to anappendectomy in humans. Conclusions: Based on the comparison of topographic and anatomical peculiarities of the location and structure of the appendix, as well as of surgery in rabbits can be concluded that the use o f rabbits as experimental animals formodeling appendectomy during practice-oriented training as analternative to engaging in exeperimental dogs is reasonable and will allow students to virtually secure knowledge of the topic and to gain practical experience of surgical intervention.