DC Field | Value | Language |
dc.contributor.author | Cucovici, Aliona | |
dc.contributor.author | Ivashynka, Andrei | |
dc.contributor.author | Fontana, Andrea | |
dc.contributor.author | Lisnic, Vitalie | |
dc.contributor.author | Leone, Maurizio A. | |
dc.date.accessioned | 2021-10-02T19:48:54Z | |
dc.date.available | 2021-10-02T19:48:54Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | CUCOVICI, Aliona, IVASHYNKA, Andrei, FONTANA, Andrea, LISNIC, Vitalie, LEONE, Maurizio A. Role of nutritional and lifestyle factors on the Amyotrophic Lateral Sclerosis progression. Results from a multicenter cross-sectional study. In: The Moldovan Medical Journal. 2021, vol. 64, no 3 (Neuro Congress Issue), p. 29. ISSN 2537-6381. | |
dc.identifier.issn | 2537-6381 | |
dc.identifier.issn | 2537-6373 | |
dc.identifier.uri | http://moldmedjournal.md/wp-content/uploads/2021/09/Congres-Neuro-2021-Spaltul-11.pdf | |
dc.identifier.uri | http://repository.usmf.md/handle/20.500.12710/18072 | |
dc.description.abstract | Background: Amyotrophic Lateral Sclerosis is a devastating, untreatable motor neuron disease with unknown causes, but nutritional and lifestyle
factors may play a role. To check this hypothesis, we conducted a multicentre cross-sectional study.
Material and methods: This study recruited 241 patients, 96 females, and 145 males; the mean age at onset – 59.9±11.8 years. According to El
Escorial criteria, 74 patients were definite ALS, 77 – probable, 55 – possible, and 35 –suspected; 187 patients had spinal onset and 54 – bulbar.
Patients were categorized into three groups, according to their ΔFS: slow (81), intermediate (80), and fast progressors (80).
Results: Current coffee consumers were 179 (74.3%), 34 (14.1%) were non-consumers, 22 (9.1%) – former consumers. The log-ΔFS was weakly
correlated with the duration of coffee consumption (p=0.034), but not with the number of cup-years, or the intensity of coffee consumption
(cups/day). Current tea consumers were 101 (41.9%), 6 (2.5%) were former-consumers, and 134 (55.6%) – non-consumers. The log-ΔFS was
weakly correlated only with the consumption duration of black tea (p=0.028) but not with the number of cup-years. Current smokers were 44
(18.3%), former smokers – 10 (4.1%), and non-smokers – 187 (77.6%). The age of ALS onset was lower in current smokers than non-smokers,
and the ΔFS was slightly, although not significantly, higher for smokers of >14 cigarettes/day. Current alcohol drinkers were 147 (61.0%), former
drinkers – 5 (2.1%), and non-drinkers – 89 (36.9%). The log(ΔFS) was weakly correlated only with the duration of alcohol consumption (p =
0.028), but not with the mean number of drinks/day or the drink-years.
Conclusions: Our study does not support the hypothesis that coffee or tea consumption is associated with the ALS progression rate, possible
minor role for smoking and alcohol drinking was suggested. | en_US |
dc.language.iso | en | en_US |
dc.publisher | The Scientific Medical Association of the Republic of Moldova | en_US |
dc.relation.ispartof | The Moldovan Medical Journal | en_US |
dc.subject | Amyotrophic Lateral Sclerosis | en_US |
dc.subject | lifestyle factors | en_US |
dc.title | Role of nutritional and lifestyle factors on the Amyotrophic Lateral Sclerosis progression. Results from a multicenter cross-sectional study | en_US |
dc.type | Other | en_US |
Appears in Collections: | The Moldovan Medical Journal, Vol. 64, No 3, September 2021
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