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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/18140
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dc.contributor.authorGolyak, Natalia-
dc.contributor.authorMalchenkova, Svetlana-
dc.date.accessioned2021-10-08T12:26:55Z-
dc.date.available2021-10-08T12:26:55Z-
dc.date.issued2021-
dc.identifier.citationGOLYAK, Natalia, MALCHENKOVA, Svetlana. In vitro dissolution profile of transdermal matrix ibuprofen patches using Paddle method. In: Revista Farmaceutică a Moldovei. 2021, vol. 45, nr. 1, pp. 52-54. ISSN 1812-5077.en_US
dc.identifier.issn1812-5077-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/18140-
dc.descriptionBelarusian State Medical University, Minsk, Republic of Belarusen_US
dc.description.abstractRezumat. Hidrogelul de poli(vinil pirolidonă) cu greutate moleculară mare (PVP) și poli(etilen glicol) 400 cu greutate moleculară mică (PEG 400) a fost utilizat ca matrice adezivă a sistemului de livrare transdermică a foribuprofenului. Au fost elaborate cinci plasturi, fiecare conţinând 0,2 ibuprofen. Testul de dizolvare a plasturilor transdermici a confirmat eliberarea ibuprofenului din matricea tuturor plasturilor și a determinat fluxul de ibuprofen. Fluxul mediu constant de ibuprofen a fost de 1,4 μg/cm2h pentru doi plasturi, 1,5 μg/cm2h pentru doi plasturi și 1,3 μg/cm2h pentru un plasture.en_US
dc.description.abstractAbstract. The hydrogel ofhigh molecular weight poly(vinyl pyrrolidone) (PVP) and low molecular weight poly(ethylene glycol) 400 (PEG 400) was used as adhesive matrix foribuprofen transdermal delivery system. Five patches were made, each containing 0,2 ibuprofen. The dissolution test for transdermal patches confirmed the release of ibuprofen from the matrix of all patches and determined the ibuprofen flux. The average constant ibuprofen flux was 1.4 μg / cm2 h for two patches, 1.5 μg/cm2 h for two patches, and 1.3 μg/cm2 h for one patch.en_US
dc.language.isoenen_US
dc.publisherAsociația Farmaciștilor din Republica Moldovaen_US
dc.relation.ispartofRevista Farmaceutică a Moldoveien_US
dc.subjectibuprofenen_US
dc.subjecttransdermal patchen_US
dc.subjectPVP: PEG hydrogelen_US
dc.subject.ddcCZU: 615.212:615.477.66en_US
dc.titleIn vitro dissolution profile of transdermal matrix ibuprofen patches using Paddle methoden_US
dc.title.alternativeProfilul de disoluţie in vitro al matricelor transdermale emplasturi cu ibuprofen utilizând metoda Padelen_US
dc.typeArticleen_US
Appears in Collections:Revista Farmaceutică a Moldovei Nr. 1 Vol. 45, 2021

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