Dyslipidemia in thyroid dysfunctions

Abstract

Introduction Dyslipidemia is a condition characterized by altered fat metabolism highlighted by changes in cholesterol, LDL-cholesterol, HDLcholesterol, triglycerides.Purpose The aim is to show the influence of the thyroid dysfunction on the lipid and mineral profiles, as well as the risks and concerns that are caused by this metabolic change. Results Substitution therapy with L-thyroxine significantly improves the above described abnormalities of lipid metabolism and increases the previously low biliary cholesterol excretion. It usually takes up to 4-6 weeks of treatment to correct the dyslipidemia caused by the malfunction of the thyroid. In result the lipid levels are back to the normal range, but the serum glucose level remains unchanged. Conclusions The increased cardiovascular risk in thyroid dysfunction was related to the deranged lipid profile, endothelial dysfunction, metabolic, hormonal, and hemodynamic changes and coagulation disturbances, decreased bone mineral density, increased risk of osteoporotic fractures, and disturbed serum calcium and phosphate levels. Material and methods Dyslipidemia in patients with thyroid disorders, Evagelos N Liberopoulos, Moses S Elisaf ‘s article form Department of Internal Medicine, University of Ioannina Medical School, Ioannina, Greece.