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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/19349
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dc.contributor.authorMatasari, Marcela-
dc.contributor.authorValica, Vladimir-
dc.contributor.authorMacaev, Fliur-
dc.contributor.authorPodgornîi, Ana-
dc.date.accessioned2021-12-10T08:40:43Z-
dc.date.available2021-12-10T08:40:43Z-
dc.date.issued2014-
dc.identifier.citationMATASARI, Marcela, VALICA, Vladimir, MACAEV, Fliur, PODGORNÎI, Ana. Development and validation of the UV spectrophotometric method for analysis of ethanol solution of Isoconazol nitrat. In: MedEspera: the 5th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2014, p. 242.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/19349-
dc.descriptionPharmaceutical and Toxicological Chemistry Department, State University of Medicine and Pharmacy “Nicolae Testemi^anu”, Chisinau, Republic of Moldovaen_US
dc.description.abstractIntroduction: The high prevalence and the constant increase of incidence of skin fungal infections and its annexes causes a continuing interest for the analysis and standardization of antifungal agents. Purpose and objectives: Validation of UV spectrophotometric method for analysis of nitrate Isoconazole obtained through original from synthetically imidazole ionic liquids. Materials and methods: Reference study (articles of journals, periodicals, European Pharmacopoeia). The object of the research was the sample of Isoconazole nitrate, synthesized in the Laboratory of Synthetic Organic Chemistry Institute, Academy of Sciences of Moldova. Instruments: UV Visible Spectrophotometer (Agilent 8453); electric balance (OHAUS). Results: The Isoconazole nitrate solution spectrum shows the well-defined spectral absorption maximum between 274 nm and 282 nm. Ethanol shows absorption maxima at other wave lengths. So it can be used as a solvent. According to the calibration straight lines, a better linearity shows the data taken at X 274 nm. In the concentration range 50-150 mg / mL, the relative standard deviation is 0.22% maximum, which is equivalent to a very good accuracy of the method. Conclusion: According to the results of the study, the UV spectrophotometric method was validated. It allows the quantitative determination of the nitrate Isoconazole in ethanol solution. This method is rapid, requiring small amounts of reagents, providing accurate and reproducible data.en_US
dc.language.isoenen_US
dc.publisherMinistry of Health of the Republic of Moldova, State Medical and Pharmaceutical University Nicolae Testemitanu, Medical Students and Residents Associationen_US
dc.relation.ispartofMedEspera: The 5th International Medical Congress for Students and Young Doctors, May 14-17, 2014, Chisinau, Republic of Moldovaen_US
dc.subjectImidazole derivativesen_US
dc.subjectisoconazole nitrateen_US
dc.subjectUV spectroscopyen_US
dc.titleDevelopment and validation of the UV spectrophotometric method for analysis of ethanol solution of Isoconazol nitraten_US
dc.typeOtheren_US
Appears in Collections:MedEspera 2014



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