USMF logo

Institutional Repository in Medical Sciences
of Nicolae Testemitanu State University of Medicine and Pharmacy
of the Republic of Moldova
(IRMS – Nicolae Testemitanu SUMPh)

Biblioteca Stiintifica Medicala
DSpace

University homepage  |  Library homepage

 
 
Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/19426
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPantea, Valeriana-
dc.contributor.authorGamaniuc, Marina-
dc.contributor.authorPopa, Veaceslav-
dc.date.accessioned2021-12-15T09:27:45Z-
dc.date.available2021-12-15T09:27:45Z-
dc.date.issued2021-
dc.identifier.citationPANTEA, Valeriana, GAMANIUC, Marina, POPA, Veaceslav. Erythrocytic antioxidant system in the administration of new coordination compounds thiosemicarbazide derivatives. In: The Moldovan Medical Journal. 2021, vol. 64, no 5, pp. 70-75. ISSN 2537-6381. doi.org/10.52418/moldovan-med-j.64-5.21.13en_US
dc.identifier.issn2537-6381-
dc.identifier.issn2537-6373-
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2020/08/633-MMJ-Spaltul-5-din-25-08-20.pdf-
dc.identifier.uridoi.org/10.52418/moldovan-med-j.64-5.21.13-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/19426-
dc.descriptionLaboratory of Biochemistry, Department of Biochemistry and Clinical Biochemistry Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of Moldovaen_US
dc.description.abstractBackground: Currently, there is a growing interest in new local coordination compounds (CC), which demonstrated antitumor properties, but their influence on the erythrocyte antioxidant system has not been studied. The aim of the study: to study the effects of CC, thiosemicarbazide derivatives –TIA-160, CMT-67 and CMJ-33 on indices of the antioxidant system indicators in erythrocytes peripheral blood in vivo experiments. Material and methods: The action of CC on superoxide dismutase, catalase, total antioxidant capacity was evaluated on a group of 34 white rats, randomly divided into 4 groups: the first control group was injected subcutaneously with saline. The other groups (2 – TIA-160, 3 – CMT-67 and 4 – CMJ-33) were given subcutaneously 3 times a week for 30 days, 0.1µM / kg CC. Results: It was established that the TIA-160 compound demonstrated the highest capacity to induce the expression of erythrocyte catalase that exceeded the control level of 1.8, which did not correlate with the enzymatic superoxide dismutase (SOD) activity. Thus, this study showed that there are differences in the mechanisms of action of thiosemicarbazone derivatives. Conclusions: The influence of tested CC on the indices of the antioxidant system is selective. This selectivity may be the base to their strong selective antiproliferative and cytotoxic action on tumor cells, but not on healthy ones.en_US
dc.language.isoenen_US
dc.publisherThe Scientific Medical Association of the Republic of Moldovaen_US
dc.relation.ispartofThe Moldovan Medical Journal: The Annual Scientific Conference of Nicolae Testemitanu State University of Medicine and Pharmacy of the Republic of Moldova on the occasion of the 76 years of activity: Research in biomedicine and health quality, excellence and performance, 20-22 October 2021en_US
dc.subjectcoordination compoundsen_US
dc.subjecterythrocytesen_US
dc.subjectantioxidant enzymesen_US
dc.subject.ddcUDC: 612.015+616-092.9en_US
dc.titleErythrocytic antioxidant system in the administration of new coordination compounds thiosemicarbazide derivativesen_US
dc.typeArticleen_US
Appears in Collections:The Moldovan Medical Journal. Vol. 64, No 5, November 2021



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2013  Duraspace - Feedback