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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/19498
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dc.contributor.authorBuga, Diana
dc.date.accessioned2021-12-21T14:39:17Z
dc.date.available2021-12-21T14:39:17Z
dc.date.issued2021
dc.identifier.citationBUGA, Diana. Epidemiology of nosocomial infections with methicillin-resistant Staphylococcus in the Republic of Moldova: summary of the doctoral thesis in medical sciences: 331.01 – Epidemiology. Chișinău, 2021, 25 p.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/19498
dc.description.abstractThe novelty of the subject. Healthcare-associated infections (HAIs) have become one of the major public health problems from the clinical, epidemiological and socio-economic perspectives. They represent a special chapter of pathology highlighted in the context of modern medical advances, determined by the diversity of diagnostic and therapeutic maneuvers, also due to the irrational use of antibiotics, especially the broad-spectrum ones, which leads to the selection of resistant bacteria [1, 2, 3, 4, 5]. Healthcare-associated infections caused by antibiotic-resistant microorganisms are one of the most important challenges for modern medicine today. A large part of Staphylococcus aureus infections are produced by a microbial pathogen resistant to a wide range of antibiotics used in the hospital environment, namely, methicillin-resistant Staphylococcus aureus (MRSA) [6]. From the first cases of MRSA to date, the problem has increased dramatically, the incidence of MRSA infections reaching endemic proportions in some hospitals. In Europe, a north-south gradient is observed, MRSA strains being rare in Scandinavian hospitals (<2%) and much more widespread in hospitals in Mediterranean countries (> 40%) [7, 8, 9]. Although in recent years the percentage of methicillin-resistant Staphylococcus aureus strains has decreased in the European Union / European Economic Area (EU / EEA), from 19.6% in 2014 to 16.9% in 2017, however, MRSA remains an important challenge at the European level, with high MRSA levels in several countries and an increased overall antimicrobial resistance [10, 11, 12, 13]. In 2017, the World Health Organization (WHO) established the most important categories of multidrug-resistant germs, which required the introduction of new therapeutic options with 3 priority levels: critical, high and medium; methicillin-resistant Staphylococcus aureus strains belonging to the high level [14, 15]. Shortly after the emergence of MRSA, it was realized that the problem of methicillin resistance involves not only coagulase-positive staphylococci (CPS), but also coagulase-negative staphylococci (CNS). Although in the beginning, these species of microorganisms were given little importance, being considered part of the normal flora of the skin and nasal mucosa, today, due to their resistance to antibacterial preparations, they have become a source of concern for the medical system. They are especially associated with the use of foreign bodies, implants, etc., which are indispensable in modern medicine [16, 17]. Increased rates of antibiotic resistance have been shown to be even a greater problem for CNS than for Staphylococcus aureus, limiting the treatment options [18, 19]. Methicillin resistance has been shown to have a negative impact on clinical and economic outcomes, especially in terms of increased morbidity and mortality and long-term hospitalization, as well as the need for additional interventions to mitigate the clinical impact [20, 21, 22, 23, 24, 25]. The ranking of staphylococci first in the etiology of bacterial infections, the annual increase in the number of methicillin-resistant staphylococcal strains and the emergence of strains resistant to spare antistaphylococcal antibiotics, place this medical condition among emerging infectious diseases [26, 27, 28, 29]. In the Republic of Moldova, studies on the incidence of infections caused by methicillin-resistant Staphylococcus (MRS) are fragmentary [28, 29, 30]. Knowledge of local epidemiology of methicillin-resistant Staphylococcus infections will contribute to raising the awareness of the problem and implementation of rational measures for surveillance and control of the given medical condition. [...]en_US
dc.language.isoenen_US
dc.subjecthealthcare-associated infectionsen_US
dc.subjectpurulent-septic infectionsen_US
dc.subjectmethicillinresistant Staphylococcusen_US
dc.subjectmethicillin-susceptible Staphylococcusen_US
dc.subjectclinical formsen_US
dc.subjectantibiotic resistanceen_US
dc.subjectrisk factorsen_US
dc.subjecttherapeutic managementen_US
dc.subjectsocio-economic impacten_US
dc.subject.ddcUDC: [616.98:579.861.2]-022.3-036.22(478)(043.2)en_US
dc.subject.meshCross Infectionen_US
dc.subject.meshSuppurationen_US
dc.subject.meshSuppuration--etiologyen_US
dc.subject.meshMethicillin-Resistant Staphylococcus aureusen_US
dc.subject.meshMethicillin-Resistant Staphylococcus aureus--epidemiologyen_US
dc.subject.meshMethicillin-Resistant Staphylococcus aureus--drug effectsen_US
dc.subject.meshStaphylococcal Infectionsen_US
dc.subject.meshStaphylococcal Infections--epidemiologyen_US
dc.subject.meshDrug Resistance, Microbialen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshConservative Treatmenten_US
dc.subject.meshMoldovaen_US
dc.titleEpidemiology of nosocomial infections with methicillin-resistant Staphylococcus in the Republic of Moldovaen_US
dc.typeOtheren_US
Appears in Collections:AUTOREFERATELE TEZELOR DE DOCTOR, DOCTOR HABILITAT

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