USMF logo

Institutional Repository in Medical Sciences
of Nicolae Testemitanu State University of Medicine and Pharmacy
of the Republic of Moldova
(IRMS – Nicolae Testemitanu SUMPh)

Biblioteca Stiintifica Medicala
DSpace

University homepage  |  Library homepage

 
 
Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/19658
Full metadata record
DC FieldValueLanguage
dc.contributor.authorDolință, Irina-
dc.date.accessioned2022-01-26T10:24:03Z-
dc.date.available2022-01-26T10:24:03Z-
dc.date.issued2012-
dc.identifier.citationDOLINȚĂ, Irina. Correlation between circulating immune complexes and expression of extracardiac manifestations in infective endocarditis. In: MedEspera: the 4th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2012, pp. 92-93.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/19658-
dc.description.abstractBackground: Infective Endocarditis is a serious infection of the heart endocardium, particularly the heart valves are associated with a high degree of illness and death. It generally occurs in patients with altered and abnormal heart architecture, in combination with exposure to bacteria through trauma and other potentially high-risk activities involving transient bacteremia. Endocarditis remains a devastating disease with a high mortality despite timely diagnosis and treatment. Objective: to establish the correlation between circulating immune complexes and the degree of expression of extracardiac manifestations in infective endocarditis and it’s utility in nowadays diagnosis.Patients and methods: To examine the role of circulating immune complexes (CIC) in infective endocarditis, we studied 51 patients with infective endocarditis (IE) for the presence of CIC, from the Institute of Cardiology from Chisinau, the Republic of Moldova. We have used ELISA method, as the elective method to identify the level of CIC. We also included in this study, the clinical examination of the patients both with normal and high levels of CIC. Results: We identified 42 patients with a high-level of CIC and 9 pacients with a normal value of CIC. Among the pacients with high-level of CIC 35 (83.3% ) had subacute endocarditis (SBE), and 7 (16.7 %) had acute infective endocarditis(AIE). Systemic deposition of immune complexes results in the vasculitic lesions clasically associated with IE: so 8 (19.04%) had peripheral lesions (Osier’s nodes, petechiae, splinter hemorrhages et.al), and 31 (80.96%) had severe immunological manifestations such as: glomerulonephritis, mycotic anevrysms.et.al. Conclusion: These findings support the hypothesis that CIC may be important in the pathogenesis of peripheral and imunological lesions in infective endocarditis.en_US
dc.language.isoenen_US
dc.publisherState Medical and Pharmaceutical University Nicolae Testemitanu, Medical Students and Residents Association, Scientific Association of Students and Young Doctorsen_US
dc.relation.ispartofMedEspera: The 4th International Medical Congress for Students and Young Doctors, May 17-19, 2012, Chisinau, Republic of Moldovaen_US
dc.subjectcirculating immune complexesen_US
dc.subjectinfective endocarditisen_US
dc.subjectclinical manifestationsen_US
dc.titleCorrelation between circulating immune complexes and expression of extracardiac manifestations in infective endocarditisen_US
dc.typeOtheren_US
Appears in Collections:MedEspera 2012



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2013  Duraspace - Feedback