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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/19724
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dc.contributor.authorRotaru, Lilia-
dc.date.accessioned2022-01-27T10:48:20Z-
dc.date.available2022-01-27T10:48:20Z-
dc.date.issued2021-
dc.identifier.citationROTARU, Lilia. Cerebrovascular disease associated with Parkinson’s disease in Moldovan cohort study. In: The Moldovan Medical Journal. 2021, vol. 64, no 6, pp. 33-36. ISSN 2537-6381. https://doi.org/10.52418/moldovan-med-j.64-6.21.06en_US
dc.identifier.issn2537-6373-
dc.identifier.issn2537-6381-
dc.identifier.urihttp://moldmedjournal.md/wp-content/uploads/2021/12/Moldovan-Med-J-December-2021-Vol-64-No-6.pdf-
dc.identifier.urihttps://doi.org/10.52418/moldovan-med-j.64-6.21.06-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/19724-
dc.description.abstractBackground: Parkinson’s disease (PD) is frequently associated with brain vascular lesions (BVLs), which may influence the severity of the disease. Material and methods: BVLs on MRI were determined in 78.4% of 111 consecutive PD patients (mean age 64.87 ± 7.69 y.o.; disease duration 50.21 ± 38.61 mo.; 48 women (43.2%), 63 men (56.8%)). Results: White matter lesions were present in 73 patients (p.) (65.77%): 61p. (54.95%) – deep white matter, 46p. (41.44%) – periventricular white matter, and 41p. (36.94%) – both locations. Lacunas were determined in 19p. (17.12%), cerebral fissures deepening – 52p. (46.85) %), perivascular spaces dilation – 34p. (30.63%), ventricular system dilation – 29p. (26.13%). Patients with and without BVLs had similar ages, ages at PD onset and disease duration. They had insignificantly higher Beck (7.26 ± 5.62 vs 6.86 ± 4.34), PDQ39 (Parkinson’s Disease Questionnaire) (59.71 ± 20.38 vs 51.94 ± 27.69) and NMS (Non-Motor Symptoms) (75.06 ± 45.21 vs 71.67 ± 26.35) scores; and lower MoCA (Montreal Cognitive Assessment) scores (21.92 ± 4.25 vs 22.38 ± 4.57). QRISK3 scores (19.68 ± 16.16 vs 12.90 ± 6.58) and levodopa equivalent daily dose (639.98 ± 223.05 vs. 439.69 ± 404.87) were significantly higher in patients with BVLs. Conclusions: Brain vascular lesions were common in our PD patients, and were associated with higher QRISK3 scores and higher levodopa equivalent daily dose, suggesting more disease severity.en_US
dc.language.isoenen_US
dc.publisherThe Scientific Medical Association of the Republic of Moldovaen_US
dc.relation.ispartofThe Moldovan Medical Journalen_US
dc.subjectParkinson’s diseaseen_US
dc.subjectbrain vascular lesionsen_US
dc.subject.ddcUDC: [616.831-005+616.858](478)en_US
dc.titleCerebrovascular disease associated with Parkinson’s disease in Moldovan cohort studyen_US
dc.typeArticleen_US
Appears in Collections:The Moldovan Medical Journal. Vol. 64, No 6, December 2021



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