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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/19929
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dc.contributor.authorTudorancea, Ionuț-
dc.contributor.authorDondas, Andrei-
dc.date.accessioned2022-02-03T10:11:43Z-
dc.date.available2022-02-03T10:11:43Z-
dc.date.issued2012-
dc.identifier.citationTUDORANCEA, Ionuț, DONDAS, Andrei. New 99mTc - silica nanoparticles radiotracer biodistribution studied through scintigraphy. In: MedEspera: the 4th Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2012, pp. 236-237.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/19929-
dc.description.abstractAim of the study: Silica nanoparticles (SNP) are a new and versatile tool for targeting drug delivery. Our aim was to investigate biodistribution of a new SNP derivate in guinea pigs, in order to identify the possible uses as a drug carrier. Materials: SNP were prepared at the Institute o f Chemistry and Bioanalytics, University o f Applied Sciences Northwestern Switzerland, Muttenz, Switzerland. One 124 nm size SNP derivate was used: AA124 - SNP carrying OH groups on the surface. Methods: The procedure of 99mTc - SNP coupling was an in-house preparation performed as follows: 1- first of all, SNP were suspended in EtOH (5mg/ml) and sonicated for 15 or 20 min for better disper­sion. 2- to this suspension, 200MBq/lml of Na99mTc04 solution was added and the suspension was stirred gently. 3- an excess of NaBH4 reducing agent was added quickly to the suspension and stirred for minimum 1 hour. Scintigraphic study design: Groups of 4 animals were intravenously administered with 37MBq/kg/ animal 99mTc-coupled AA124 SNP. Control groups received 37MBq/kg animal 99mTc. A dual head Siemens gamma camera with high resolution parallel collimators was used. The image acquisitions protocol started with a dynamic image acquisition for 60 seconds (1 image/sec), followed by a dynamic image acquisition for 4 minutes (1 image/min) and static planar images (256x256 Matrix, Zoom 2) every 15 minutes for a duration of 2h. The animals were sacrificed after 120 min and different organs were extracted entirely and submited to gamma camera. Results: Following the i.v. administration, AA124 SNP did not penetrate the blood brain barrier. SNP were present in all the organs investigated except the brain, with different target/non target indexes, that were graphically represented for each of them. Conclusion: These step results represent a promising support for the idea of using the AA124 as container for modular drug delivery system with promising future in therapeutics.en_US
dc.language.isoenen_US
dc.publisherState Medical and Pharmaceutical University Nicolae Testemitanu, Medical Students and Residents Association, Scientific Association of Students and Young Doctorsen_US
dc.relation.ispartofMedEspera: The 4th International Medical Congress for Students and Young Doctors, May 17-19, 2012, Chisinau, Republic of Moldovaen_US
dc.subjectnanoparticlesen_US
dc.subjectradiotraceren_US
dc.subjectbiodistributionen_US
dc.subjectscintigraphyen_US
dc.titleNew 99mTc - silica nanoparticles radiotracer biodistribution studied through scintigraphyen_US
dc.typeOtheren_US
Appears in Collections:MedEspera 2012



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