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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/20142
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dc.contributor.authorBacinschi, Andrei-
dc.date.accessioned2022-02-15T09:51:28Z-
dc.date.available2022-02-15T09:51:28Z-
dc.date.issued2010-
dc.identifier.citationBACINSCHI, Andrei. Antibacterial properties of naftochinone derivatives. In: MedEspera: the 3rd Internat. Medical Congress for Students and Young Doctors: abstract book. Chișinău: S. n., 2010, p. 7.en_US
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/20142-
dc.description.abstractFrom ancient time was known that vegetable alkaloids of green peals and walnut’’s leaves have antimicrobial and antifungal effects. It was found that these structures of thewalnuts contain diferent compounds, derivatives of naftochinone, which were degradeted untill natural alkaloids or actulamentes obtained through the synthesis (nucina, benzil-alcoholic solution of juglone). Studies in vitro demonstrate that benzil-alcoholic solution of juglone in concentration 0,02%; 0,01%; 0,006%; 0,0003%; 0,0001%; 0,00038% and 0,00019% poses a pronounce antibacterial activity against grampositive microorganisms (Staphilococcus aureus (Wood-209), Streptococcus faecalis) and gramnegative (Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris). Therefore, growing of majority of the microorganismal strains was inhibited by the juglone solution 0,00019% at the same time benzil-alcoholic solution manifests the same effect in double concentration gram-positive cocii (Streptococcus faecalis and Staphilococcus aureus, which was killed by benzil-alcoholic solution of juglone 0,00009%) with more sensibility to this preparate. Experimental researches in vitro elucidated that benzil-alcoholic solution of juglone in concentration 0,05%; 0,025%; 0,0125%; 0,0062%; 0,0031%; 0,00155%; 0,00077%; 0,00038%; 0,00019%; 0,00009%; 0,000045%manifestes antifungal properties against Candida albicans, Aspergillus niger, Aspergillus fumigatus, Penicillium. In these conditions activity against Candidas is 4 times higher, against aspergilles and penicillium 2 times, more intensive than standart benzyl-alcoholic solution. These data demonstrates that antibacterial and antifungal action of the following preparate is determined as a synthetic derivative of naftochinone - juglone.en_US
dc.language.isoenen_US
dc.publisherNicolae Testemitanu State Medical and Pharmaceutical Universityen_US
dc.relation.ispartofMedEspera: The 3rd International Medical Congress for Students and Young Doctors, May 19-21, 2010, Chisinau, Republic of Moldovaen_US
dc.titleAntibacterial properties of naftochinone derivativesen_US
dc.typeOtheren_US
Appears in Collections:MedEspera 2010

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