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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/22233
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dc.contributor.authorSegal, Daniel-
dc.date.accessioned2022-11-08T14:59:24Z-
dc.date.available2022-11-08T14:59:24Z-
dc.date.issued2022-
dc.identifier.citationSEGAL, Daniel. The central role of podocyte foot processes in the normal conditions and glomerular diseases: [poster]. In: Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 19-21 octombrie 2022: culegere de postere electronice. 2022, p. 22.en_US
dc.identifier.urihttps://conferinta.usmf.md/wp-content/uploads/culegere_de_postere_2022.pdf-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/22233-
dc.description.abstractIntroduction: Podocytes cells are part of the filtration barrier that prevent loss of proteins into urine. Podocytes injury that present in various range of diseases result in proteinuria. The mechanisms of injuries can vary, but all them lead to the foot process effacement of podocytes. Purpose: Studying the morphology and normal function of the podocytes foot process and of associated changes of them within glomerular diseases. Material and methods: The research is based on literary sources that were analyzed using PubMed, NCBI and Medline published within the period of 2012-2022. Results: The analyzed researches showed that the podocyte foot processes are attached to the glomerular capillaries at the glomerular basement membrane (GBM) by forming intercellular junctions that form slit diaphragm of filtration barrier. Morphologically, the podocytes are atypical polarized epithelial cells that are divided into 3 separate structural and functional elements: a large cell body, major extending processes, and minor foot processes. The apical domain is negatively charged, which is limiting the passage of albumin into urine. The injured podocytes undergo effacement, and in result reduction of filtration barrier function and proteinuria. Conclusions: The podocyte foot processes are attached to the glomerular capillaries at the glomerular basement membrane (GBM) by forming intercellular junctions that form slit diaphragm of filtration barrier. The podocytes are divided into 3 separate structural and functional elements: a large cell body, major extending processes, minor foot processes. The apical domain is negatively charged, which is limiting the passage of albumin into urine. The injured podocytes undergo effacement, and in result reduction of filtration barrier function and proteinuria.en_US
dc.language.isoenen_US
dc.publisherUniversitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldovaen_US
dc.relation.ispartofConferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 2022en_US
dc.subjectpodocyteen_US
dc.subjectfiltration barrieren_US
dc.subjectglomerular diseaseen_US
dc.subjectproteinuriaen_US
dc.titleThe central role of podocyte foot processes in the normal conditions and glomerular diseasesen_US
dc.typeOtheren_US
Appears in Collections:Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 19-21 octombrie, 2022: Culegere de postere

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