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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12710/22370
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dc.contributor.authorNiguleanu, Adriana-
dc.contributor.authorLesnic, Evelina-
dc.contributor.authorPrivalova, Elena-
dc.contributor.authorGhinda, Serghei-
dc.date.accessioned2022-11-11T08:09:34Z-
dc.date.available2022-11-11T08:09:34Z-
dc.date.issued2022-
dc.identifier.citationNIGULEANU, Adriana, LESNIC, Evelina, PRIVALOVA, Elena, GHINDA, Serghei. Pathogenetic diversity of the immune disturbances in patients with pulmonary drug susceptible and drug resistant tuberculosis: [poster]. In: Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 19-21 octombrie 2022: culegere de postere electronice. 2022, p. 115.en_US
dc.identifier.urihttps://conferinta.usmf.md/wp-content/uploads/culegere_de_postere_2022.pdf-
dc.identifier.urihttp://repository.usmf.md/handle/20.500.12710/22370-
dc.description.abstractIntroduction. The immune response to M. tuberculosis infection consists mainly in the activation of the cell-mediated immune response (CIR). Natural resistance (NR) and humoral immunity (HI) contribute to a long-lasting immune resistance to reinfection and reactivation of latent infection. Purpose. Assessment of the pathogenetic diversity of immune disorders (ID) in serum in patients with pulmonary susceptible tuberculosis (S-TB) and MDR-TB. Material and methods. Indicators of CIR (CD3+), NR (phagocytic number), and HI (CD19 +) were determined in 36 healthy individuals (control group-CG), 57 new cases with S-TB (study group 1-SG1) and 72 new cases of MDR-TB (study group 2-SG2). The average was reported to the CG which was the reference value, %. Range 1-33% of the reference value in CG considered the 1st degree of ID, 34-66% - the 2nd degree ID, >66% -the 3rd degree ID, as positiveimmune overactivity (IOA) and negative-immune deficiency (ID). Results. Indices of CIR showed in the SG1 the cell-mediated immune defficiencies (CID) in 23 (41%) cases all of the 1st degree ID, in the SG2- CID of the 1st degree was in 60 (82%) and of 2nd degree CID - in 10 (18%) of cases. In the SG1 the CID was established in 32 (91%) and HI deficiencies (HID) in 3 (9%). In the SG2 the CID was in 26 (90%), HID in 6 (10%) and NR deficiencies (NRD) in 8(23%) of cases. SG1 the 1st degree IOA was detected in 26(43%), 2nd degree 11(31%) and 3rd degree 9 (26%) cases. In SG2 the 1st degree IOA was established in 10 (16%), 2 nd degree in 22 (36%) and 3 rd degree in 29 (53%) of cases. Conclusion. The deficiencies of the CIR were more frequently, established in patients with MDR-TB, associated with a higher rate of NRD and HID and a higher degree of IOA.en_US
dc.language.isoenen_US
dc.publisherUniversitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldovaen_US
dc.relation.ispartofConferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 2022en_US
dc.subjecttuberculosisen_US
dc.subjectcell-mediated immune responseen_US
dc.subjectnatural resistanceen_US
dc.subjecthumoral immunityen_US
dc.titlePathogenetic diversity of the immune disturbances in patients with pulmonary drug susceptible and drug resistant tuberculosisen_US
dc.typeOtheren_US
Appears in Collections:Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 19-21 octombrie, 2022: Culegere de postere

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