DC Field | Value | Language |
dc.contributor.author | Bălănuță, Tatiana | - |
dc.contributor.author | Groppa, Stanislav | - |
dc.date.accessioned | 2022-11-11T10:04:30Z | - |
dc.date.available | 2022-11-11T10:04:30Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | BĂLĂNUȚĂ, Tatiana, GROPPA, Stanislav. Peripheral neuropathy associated with SARS-CoV-2 infection: [poster]. In: Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 19-21 octombrie 2022: culegere de postere electronice. 2022, p. 123. | en_US |
dc.identifier.uri | https://conferinta.usmf.md/wp-content/uploads/culegere_de_postere_2022.pdf | - |
dc.identifier.uri | http://repository.usmf.md/handle/20.500.12710/22389 | - |
dc.description.abstract | Introduction.
Coronavirus disease 2019 (COVID-19) is a contagious disease caused by SARS-CoV-2.
Symptoms of COVID-19 include fever, cough, headache, fatigue, breathing difficulties, and loss
of smell or taste. Neurological complications have been reported in the context of COVID19 infection both in the acute and subacute phase, as part of the post-COVID syndrome. To the
best of current knowledge, observational investigations reported peripheral nervous system
involvement in up to 8.9 % of people.
Material and methods. Anamnesis, clinical and paraclinical data were taken from medical
records in Institute of Emergency Medicine. Patients were investigated by RT-PCR, lung
radiography, brain and lung computed tomography (CT), electrophysiological examen. The
literature on similar cases has been studied. The exclusion criteria were: diabetes; presence of
premorbid neuropathy or premorbid symptoms compatible with diagnosis of neuropathy; alcohol
abuse; cancer; family history of genetic neuropathy; CPK values beyond the normal range.
Purpose. Description of 9 patients with peripheral polyneuropathy, as a secondary
neurological complication associated with SARS-CoV-2.
Results. Peripheral nerve conduction examination was performed using a Synergy
on Nicolet®EDX, by Natus Neurology. All patients had a standard battery of
nerve conduction motor and sensory studies, including median, ulnar, peroneal,
sural and tibial nerves on both sides, using both recording and stimulating surface
electrode. Following electrical stimuli of the different nerves, motor nerve conduction was examined by recording the
compound muscle action potential (CMAP) from surface
electrodes overlying the muscle supplied by each motor nerve.
The patients presented at different intervals after suffering the
infection, evidenced by 2 negative nasopharyngeal tests with 48 hours
between them and discharged from the hospital with progressive muscle
weakness in the limbs, especially the involvement of the proximal
muscles mainly in the lower limbs with areflexia. Electrophysiological examination were performed which confirmed the diagnosis
of demyelinating polyneuropathy in 3 patients, axonal multiple mononeuropathy
in 5 patients and axonal mononeuropathy in 1 patients, meeting the
electrophysiological criteria 2. 5 patients received corticosteroids with marked
improvement in two of them, and minimal improvement in the other three
patients. The other 4 patients did not receive specific treatment.
Conclusions.
This case series describes a variety of unique presentations of
peripheral neuropathies after mild-severe COVID-19 infection.
- Neurological manifestations appear to be more frequent in
patients who have developed severe disease and in the elderly.
- Peripheral neuropathies in patients with COVID-19 are frequent
result from immune mechanisms and neurotoxic side effects of drugs applied to treat COVID-19 and, from the compression of peripheral nerves
after prolonged bedding on the ICU, but we must not exclude the neurotropism of
the SARS-CoV2 virus. 3
- Management of peripheral nerve injury in COVID-19 survivors should be included
in future COVID-19-specific rehabilitation programs in order to prevent long-term
sequelae. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Universitatea de Stat de Medicină şi Farmacie "Nicolae Testemiţanu" din Republica Moldova | en_US |
dc.relation.ispartof | Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 2022 | en_US |
dc.subject | peripheral polyneuropathy | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | EMG | en_US |
dc.subject | NCS | en_US |
dc.title | Peripheral neuropathy associated with SARS-CoV-2 infection | en_US |
dc.type | Other | en_US |
Appears in Collections: | Conferinţa ştiinţifică anuală "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță", 19-21 octombrie, 2022: Culegere de postere
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